grant
iPSC-derived macrophages as a model to study the genetic basis of inter-individual variation in immune responses to pathogens
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 24 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2026ATAC sequencingATAC-seqATACseqAccuracy of DiagnosisAdoptedAfricanAntibiotic AgentsAntibiotic DrugsAntibioticsAsian AmericansAssay for Transposase-Accessible Chromatin using sequencingCell LineCellLineCessation of lifeChromatinCommunicable DiseasesComparative StudyComputational BiologyDataDeathDiseaseDisorderEnhancersEnvironmental FactorEnvironmental Risk FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEuropeanGene ExpressionGene FrequencyGene TranscriptionGene variantGeneralized GrowthGenesGeneticGenetic DiseasesGenetic TranscriptionGenetic studyGenotypeGrippeGrowthHealthHistone AcetylationHourHumanHuman GenomeImmuneImmune responseImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunologyIndividualIndividual DifferencesInfectionInfectious AgentInfectious DiseasesInfectious DisorderInflammatoryInfluenzaInfluenza VirusInnate Immune ResponseLimesM tbM tuberculosisM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMacrophageMapsMeasuresMicrobeMiscellaneous AntibioticModelingModern ManModernizationMolecularMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMφNatural SelectionsNaturePersonsPopulationPopulation GeneticsPredispositionPreventative strategyPrevention strategyPreventive strategyProxyQTLQuantitative Trait LociRNA ExpressionRegulatory PathwayResearch DesignResolutionRiskSamplingShapesStrains Cell LinesStudy TypeSusceptibilityTB infectionTechnologyTestingTimeTissue GrowthTranscriptionTuberculosisTwin Multiple BirthTwinsVaccinesVariantVariationWorkallelic frequencyallelic variantassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingcomputer biologycultured cell linecytokinediagnostic accuracydisseminated TBdisseminated tuberculosisenvironmental riskepigenetic variationepigeneticallyepigenomeexperimentexperimental researchexperimental studyexperimentsfightingflu infectionflu virus infectionfunctional genomicsgenetic conditiongenetic disordergenetic variantgenome scalegenome-widegenomewidegenomic varianthigh definitionhigh-resolutionhost responsehuman whole genomeiPSiPSCiPSCsimmune system responseimmunoresponseimprovedin vitro Assayinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinfected with fluinfected with flu virusinfected with influenzainfected with influenza virusinfection due to Mycobacterium tuberculosisinfectious organisminfluenza infectioninfluenza virus infectioninfluenzavirusinnovateinnovationinnovativeinsightinter-individual variabilityinter-individual variationmtbnovelontogenypathogenpressurepromoterpromotorpublic health relevanceresolutionsresponsestudy designtraittuberculosis infectiontuberculous spondyloarthropathy
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Project Summary
Infectious diseases have always been a major health problem throughout the world, imposing a strong selective
pressure on the human genome. Despite the recent advent of vaccines and antibiotics, infectious diseases cause
nearly 15 million deaths every year. Although a significant proportion of inter-individual variation in…
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