grant
Involvement of dopamine signaling in chronic pain-induced negative affective state and nicotine use comorbidity
NIHUS FederalResearch GrantFY202621+ years oldAcademic skillsAddressAdultAdult HumanAffectiveAffective DisordersAffective SymptomsAnabolismAnalgesia TestsAnhedoniaAnimalsAnxietyAssayAttenuatedBehaviorBehavioralBindingBioassayBiological AssayBrainBrain Nervous SystemCell Communication and SignalingCell SignalingChalkChronic intense painCognitive ManifestationsCognitive SymptomsCommon Rat StrainsCorpus StriatumCorpus striatum structureCyclicityD(2) Dopamine Receptor GeneD2 receptorD2DRD2DR GeneD2RD2R GeneDA NeuronDRD2DRD2 ReceptorDRD2 geneDataDevelopmentDimensionsDiseaseDisorderDopamineDopamine AntagonistsDopamine D2 ReceptorDopamine Receptor AntagonistsDopamine Receptor D2 GeneDopamine neuronDopaminergic AntagonistsEducational process of instructingEducational workshopEncephalonGoalsGrantHealth CareHealth Care CostsHealth CostsHistoryHumanHydroxytyramineIndividualInfumorphInfusionInfusion proceduresIntakeInterventionInterviewIntracellular Communication and SignalingIntravenousInvestigationKadianKnowledgeLaboratoriesLinkMS ContinMSirMaintenanceMeasuresMediatingMediationMental DepressionMentorsModelingModern ManMolecular InteractionMood DisordersMorphiaMorphineMotivationNegotiatingNegotiationNeurobiologyNicotineNicotine DependenceNicotine Use DisorderNociception TestsNucleus AccumbensOramorphOramorph SRPainPain AssessmentPain MeasurementPain measurePainfulPathway interactionsPatientsPeriodicityPre-Clinical ModelPreclinical ModelsPrincipal InvestigatorProductivityPsychiatryPsychological reinforcementPublic HealthRatRats MammalsRattusRecording of previous eventsReinforcementReportingResearchRewardsRhythmicityRiskRisk FactorsRoxanolScanningScientistSelf AdministeredSelf AdministrationSensorySignal TransductionSignal Transduction SystemsSignalingSmokingStatex SRStriate BodyStriatumStudentsSubstance abuse problemSystemTeachingTechnical ExpertiseTherapeutic InterventionTobacco ConsumptionTobacco useTrainingVentral Tegmental AreaWorkWorkshopWritingabuse liabilityabuse of substancesabuse potentialadulthoodanxiety-like behaviorattenuateattenuatesbiological signal transductionbiosynthesiscareercell typechronic painchronic pain patientco-morbidco-morbiditycomorbidityconferenceconventiondepressiondevelopmentaldopaminergic neurondrug reinforcementexposure to nicotineextracellularfaculty mentorhigh rewardhistorieshuman datain vivoindividualized therapeuticinfusionsinsightintervention therapynegative affectnegative affectivityneural controlneural regulationneurobiologicalneurobiological mechanismneurochemicalneurochemistryneuromodulationneuromodulatoryneuronal circuitneuronal circuitryneuroregulationnicotine addictionnicotine consumptionnicotine dependentnicotine exposurenicotine self-administrationnicotine useoptogeneticspain assaypain sensitivitypathwaypatient with chronic painpersonalized therapeuticpharmacologicprogramsreward circuitryskillsstriatalsubstance abusesubstance usesubstance usingsummitsymposiasymposiumtechnical skillstherapeutic agent developmenttherapeutic developmenttobacco product usevapingventral tegmentum
Description preview
Nicotine addiction among individuals with chronic pain is a serious public health concern with significant health- care expenses and lost productivity. Chronic pain-associated negative affective state, such as anxiety, is a risk factor for tobacco use. Greater chronic pain intensity increases sensitivity to anxiety, which is, in turn, associated…
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