grant
Investigation of Synthetic DNA-based Viral Particles for Spatially Controlled Antigen Presentation
Organization MASSACHUSETTS INSTITUTE OF TECHNOLOGYLocation CAMBRIDGE, UNITED STATESPosted 2 Aug 2021Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20262019 novel corona virus2019 novel coronavirus2019-nCoVAIDS VirusAIDS focused researchAIDS related researchAIDS researchAIDS scienceAIDS specific researchAb responseAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdjuvantAffectAffinityAnimal ModelAnimal Models and Related StudiesAntibody FormationAntibody ProductionAntibody ResponseAntigen PresentationAntigen TargetingAntigenic DeterminantsAntigensB blood cellsB cellB cell differentiation factorB cell growth factorB cell stimulating factor 2B cellsB-Cell ActivationB-Cell DevelopmentB-Cell Differentiation FactorB-Cell Differentiation Factor-1B-Cell Differentiation Factor-2B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1B-Cell Stimulatory Factor-2B-CellsB-LymphocytesB-cellB-cell receptor repertoire sequencingB-cell receptor sequencingBCDFBCDF-1BCGFBCGF-1BCR repertoire sequencingBCR seqBCR sequencingBCRseqBCSF 1BSF-1BSF-2BSF1BSF2Binding DeterminantsBinding SitesBinetrakinC1 qC1qCOVID-19 virusCOVID19 virusCell BodyCell CommunicationCell InteractionCell-to-Cell InteractionCellsCharacteristicsChemicalsClinicalCoV-2CoV2Combining SiteCommunicable DiseasesComplementComplement 1qComplement C1qComplement ProteinsCuesDNADNA EndonucleaseDNA mutationDNase IDeoxyribonuclease IDeoxyribonucleic AcidDevelopmentEngineeringEpitopesFollicular Dendritic CellsFormulationFundingFutureGenerationsGeneticGenetic ChangeGenetic defectGenetic mutationGeometryGerminal CenterGlycansGoalsGrippeHIVHIV AntibodiesHIV InfectionsHIV focused researchHIV investigationHIV related researchHIV researchHIV scienceHIV specific researchHIV vaccinatedHIV vaccinationHIV viral infectionHIV virus infectionHIV-1 infectionHIV-1 vaccinationHIV-Associated AntibodiesHPGFHTLV-III AntibodiesHTLV-III-LAV AntibodiesHealthHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHemagglutininHepatocyte-Stimulating FactorHospital AdmissionHospitalizationHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III AntibodiesHumoral ImmunitiesHybridoma Growth FactorIFN-beta 2IFNB2IL-15IL-4IL-6IL15IL15 ProteinIL21IL4 ProteinIL6 ProteinIg Somatic HypermutationImmuneImmune Cell ActivationImmune TargetingImmune responseImmune systemImmunesImmunizationImmunochemical ImmunologicImmunoglobulin Somatic HypermutationImmunologicImmunologic ReceptorsImmunologicalImmunological ReceptorsImmunologicallyImmunologicsIn SituInducer CellsInducer T-LymphocytesInfection by HIV-1Infection from HIV-1Infection of HIV-1Infection preventionInfectious DiseasesInfectious DisorderInfluenzaInfluenza AInfluenza A virusInfluenza Viruses Type AInfluenzavirus AInterleukin-15Interleukin-15 PrecursorInterleukin-4Interleukin-4 PrecursorInterleukin-6InvestigationInvestigation on HIVKO miceKnock-out MiceKnockout MiceLAV AntibodiesLAV-HTLV-IIILicensingLymph Node Reticuloendothelial SystemLymph node properLymphadenopathy-Associated AntibodiesLymphadenopathy-Associated VirusLymphatic nodesLymphocyte Stimulatory Factor 1MCGF-2MGC9721MGI-2Mast Cell Growth Factor-2MemoryMetabolic GlycosylationModern ManMutationMyeloid Differentiation-Inducing ProteinNull MouseOrthomyxovirus Type APancreatic DNaseParticulatePathogenicityPathway interactionsPhasePlasmacytoma Growth FactorPolishesPolysaccharidesPopulationPrevent infectionPreventative vaccinePreventive vaccineProphylactic vaccineProtein SubunitsProteinsReactive SiteRodRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Scaffolding ProteinSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2SourceStructure of germinal center of lymph nodeSubunit VaccinesT cell responseT memory cellT-Cell EpitopesT-Cell Growth Factor 2T-CellsT-Independent AntigensT-LymphocyteT-Lymphocyte EpitopesTestingTherapeuticThymonucleaseThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemThymus-Independent AntigensTitrationsType A InfluenzaVaccinationVaccine DesignVaccinesViralViral Gene ProductsViral Gene ProteinsViral ProteinsVirus-HIVVirus-like particleWorkWuhan coronavirusacetyl-LDL receptoracetylated LDL receptoractivated B cellsanalogantibody biosynthesisantibody-based immunityclinical relevanceclinically relevantcombatcomplementationcoronavirus disease 2019 viruscoronavirus disease-19 viruscytokinedesigndesigningdevelopmentalfluflu infectionflu virus infectionfuture pandemicgenome mutationglycosylationhCoV19host responsehuman immunodeficiency virus infectionhuman immunodeficiency virus researchhumanized micehumanized mouseimmune activationimmune receptorimmune system responseimmunogenimmunoglobulin biosynthesisimmunoresponseimprovedin vivoinfected with HIVinfected with fluinfected with flu virusinfected with human immunodeficiency virusinfected with influenzainfected with influenza virusinfluenza infectioninfluenza virus infectioninterestinterferon beta 2interleukin-21lymph glandlymph nodeslymphnodesmemory T lymphocytemodel of animalmolecular imagingmolecule imagingmouse modelmurine modelnCoV2nano particlenano particulatenano-sized particlenanoparticlenanoparticulatenanosized particleneutralizing antibodynew vaccinesnext generation vaccinesnext pandemicnovel vaccinespan influenza vaccinepan influenza viral vaccinepan influenza virus vaccinepandemic concernpandemic potentialpandemic riskpandemic threatparticlepathogenpathwayresearch addressing HIVresearch in HIVresearch into HIVresearch on HIVresearch on human immunodeficiency virusresearch to address HIVresponsescaffoldscaffoldingscavenger receptorscience on HIVscience to address HIVsocial rolesomatic hypermutationstemstudies on HIVsynthetic DNAsynthetic constructthymus derived lymphocytetraffickinguniversal flu vaccineuniversal influenza vaccineuniversal influenza virus vaccineuniversal vaccineuniversal vaccine against fluuniversal vaccine against influenzavaccination against HIVvaccination against HIV-1vaccination with HIVvaccine platformvirus proteinvirus-like nanoparticlesviruslike particle
Description preview
PROJECT SUMMARY
HIV and influenza pose major health burdens in the US and worldwide, claiming hundreds of thousands of lives
annually, with the latter additionally posing a significant pandemic threat. Protein subunit vaccines formulated as
nanoparticles with multivalent display of pathogenic immunogens are a proven, successful strategy to safely…
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