grant
Investigation of Pallidal Neurons in Motor Inhibition
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 20 Feb 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY202621+ years old6-OHDA6-hydroxydopamineAdultAdult HumanAnimal ModelAnimal Models and Related StudiesAxonBasal GangliaBasal NucleiBasal Transcription FactorBasal transcription factor genesBehavioralCAGH44Calcium-Binding ProteinsCell BodyCell Communication and SignalingCell SignalingCellsChronicCorpus StriatumCorpus striatum structureDA NeuronDiseaseDisorderDopamineDopamine neuronDorsalDysfunctionElectrophysiologyElectrophysiology (science)ElementsFOXP2FOXP2 geneForkhead Box P2Functional disorderFundingGeneral TaxonomyGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGlobus PallidusGoalsHydroxytyramineInterventionIntracellular Communication and SignalingInvestigationKnowledgeLesionLocomotor ActivityMiceMice MammalsModelingMolecularMonitorMotorMotor ActivityMotor CellMotor NeuronsMotor outputMovementMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyOpticsOxidopamineParalysis AgitansParkinsonParkinson DiseaseParvalbuminsPathway interactionsPatternPhysiopathologyPlayPrimary ParkinsonismProcessPropertyRegulationReporterResearchRoleSeriesShapesSignal TransductionSignal Transduction SystemsSignalingSiteSpeedStriate BodyStriatumSubstantia NigraSubstantia nigra structureSurvey InstrumentSurveysSymptomsSynapsesSynapticTNRC10TaxonomyTestingTherapeuticTimeTranscription Factor Proto-OncogeneTranscription factor genesTranslationsTrinucleotide Repeat-Containing Gene 10adulthoodbiological signal transductionbody movementcell typedopaminergic neuronelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsimprovedin vivoinsightmodel of animalmotoneuronmotor behaviormotor controlneuralneural cell bodyneuronalneuronal cell bodyopticaloptogeneticspallidumpatch clamppathophysiologypathwaysocial rolesomastatisticsstriatalsynapsetooltranscription factortranslation
Description preview
Project Summary
The long-term goal of this project is to deepen our understanding of how the external globus pallidus (GPe)
within the basal ganglia controls movement and how it goes awry in Parkinson’s disease (PD). Despite
compelling evidence that the GPe plays a critical role in regulating motor activity, its neuronal composition has
been…
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