grant
Investigation of Intercalated (I) Motif DNA Structure at Telomeric Cytosine-Rich Strand in Human Cells Genetically Altered for DNA Helicases
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY20251H-Purin-6-amine3-D3-Dimensional3DAdenineAntibodiesApoptosisApoptosis PathwayBase PairingBindingBiochemicalBiologicalCRISPRCRISPR/Cas systemCancer TreatmentCell AgingCell BodyCell Cycle ArrestCell DeathCell LineCell SenescenceCellLineCellsCellular AgingCellular SenescenceCentromereChromosomesClustered Regularly Interspaced Short Palindromic RepeatsComputational algorithmCytosineDNADNA DamageDNA HelicasesDNA InjuryDNA Polymerase IDNA Polymerase alphaDNA PolymerasesDNA ReplicationDNA SequenceDNA StructureDNA SynthesisDNA Unwinding ProteinsDNA biosynthesisDNA fiber analysisDNA fiber approachDNA fiber assayDNA fiber combingDNA fiber methodDNA fiber spreadingDNA fiber techniqueDNA unwinding enzymeDNA-Dependent DNA Polymerase IDNA-Dependent DNA PolymerasesDNA-Directed DNA PolymeraseDeoxyribonucleic AcidDetectionE coliE. coliEnzyme InteractionEscherichia coliG-QuadruplexG-Quadruplexes DNAG-Quartet StructuresG-QuartetsG-TetradsG4-DNAGene ExpressionGenesGenomicsGuanineHumanHuman GenomeImmunofluorescenceImmunofluorescence ImmunologicIn VitroIntermediary MetabolismInvestigationKlenow FragmentKnock-outKnockoutLigandsMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMetabolic PathwayMetabolic ProcessesMetabolismModern ManMolecularMolecular InteractionPIN2PhenotypePol IProgrammed Cell DeathPromoter RegionsPromotor RegionsProteinsReagentRecombinantsRegulationReplicative SenescenceReportingResearchResolutionSWNTStrains Cell LinesStructureTERF1TERF1 geneTRF GeneTRF ProteinTRF1TechniquesTelomeraseTelomeric Repeat Binding Factor 1TestingThymineVitamin B4Workanti-cancer therapybiologiccancer therapycancer-directed therapycarboxylatecell typechemical bondcomputer algorithmcultured cell lineexperimentexperimental researchexperimental studyexperimentsgenetic promoter elementgenetic promoter sequencehelicasehuman whole genomein vivointercalationmutantnecrocytosisnovelpharmacologicpreservationpreventpreventingpromoterpromoter sequencepromotorreplicative agingresolutionsresponsesenescencesenescentsingle walled carbon nano tubesingle walled carbon nanotubeskillssmall moleculetelomerethree dimensional
Description preview
The I-motif is a cytosine-rich DNA sequence that forms a non-canonical DNA structure deviating from the conventional chemical bonding rules that dictate the three-dimensional arrangement of the DNA double helix with strict complementary base pairing (adenine (A): thymine (T); guanine (G): cytosine (C)) and a defined stacking arrangement of the…
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