grant
Investigation of epithelial cell biology in preclinical mouse models of early-onset EoE
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 15 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20260-11 years old3-D3-Dimensional3D5-IsothiocyanatofluoresceinAcuteAddressAdhesion MoleculeAffectAlbuminsAntigen PresentationAssayAttenuatedAwardBasal CellBasal Cell HyperplasiaBasal Transcription FactorBasal transcription factor genesBasement membraneBindingBioassayBiological AssayBiopsy SampleBiopsy SpecimenCD74 antigenCLDN1CRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCell Communication and SignalingCell SignalingCellsCellular biologyChildChild YouthChildhoodChildren (0-21)ChronicClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexCytokine ReceptorsCytotacinCytotactinDataData SetDevelopmentDiseaseDisorderDsg1 antigenDysfunctionEosinophilic EsophagitisEpithelial Cell ProliferationEpithelial CellsEpitheliumEsophageal DiseasesEsophageal DisorderEsophagusExpression SignatureFITCFeasibility StudiesFluoresceinFluorescein-5-isothiocyanateFoundationsFunctional disorderFutureGene Expression ProfileGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic ModelsGenetic TranscriptionHexabrachionHistologicHistologicallyHumanHyperplasiaHyperplasticIL-13IL-13 OverexpressionIL13Ia associated invariant chainImmuneImmunesIncidenceInflammationInflammatoryInstitutionInterleukin-13Interleukin-13 OverexpressionIntracellular Communication and SignalingInvestigationIsothiocyanatesKnock-outKnockoutLettersLinkMIF receptorMMIF receptorsMacrophage Migration Inhibition FactorsMacrophage Migration Inhibitory FactorMeasuresMediatingMembraneMiceMice MammalsMigration Inhibition FactorMigration Inhibitory FactorModelingModern ManMolecularMolecular InteractionMorbidityMurineMusNuclearOccluding JunctionsOrganoidsPFAN proteinPathogenesisPathway interactionsPatientsPemphigus foliaceus antigenPermeabilityPhysiciansPhysiopathologyPilot ProjectsProliferatingProteinsProteomicsRNA ExpressionResearchResistanceRoleScientistSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStratum corneum basic proteinSystemTenascinTenascin-CTestingTherapeuticTight JunctionsTransactivationTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransgenic MiceTransgenic OrganismsWeaningWorkWound modelsZonula Occludensadult youthantagonismantagonistarylpyruvate keto-enol tautomeraseattenuateattenuatesbiological signal transductioncell adhesion proteincell biologyclass II associated invariant chainclaudin-1claudin-1 proteincohortcytokinedesmoglein 1developmentaldiseases of esophagusearly onsetepithelial woundesophagus disorderexperimentexperimental researchexperimental studyexperimentsfilaggrinfilagringene expression patterngene expression signaturehealth care burdenin silicoin vitro Assayin vivoinhibitorinsightinvariant chainkidsloss of functionmacrophage migration inhibitory factor receptormembrane structuremouse modelmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetp-hydroxyphenylpyruvate tautomerasepathophysiologypathwaypediatricphenylpyruvate tautomerasepilot studypotential biological markerpotential biomarkerpre-clinicalpreclinicalprogramspromoterpromotorresistantscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletherapeutic targetthree dimensionaltrans-activationtranscription factortranscriptional profiletranscriptional signaturetransgenicwound healing modelsyoung adultyoung adult ageyoung adulthoodyoungster
Description preview
PROJECT SUMMARY
Eosinophilic esophagitis (EoE) is a newly described immune-mediated disease and a leading cause of
esophageal morbidity in children and young adults. Histologically, pediatric EoE is characterized by esophageal
basal cell hyperplasia (BCH) and extensive Th2-associated inflammation. Despite many advances in our
understanding of the…
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