grant
Investigation in the role of L-type Ca2+ channel CaV1.2 in Achilles tendinopathy
Organization UNIVERSITY OF ROCHESTERLocation ROCHESTER, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025(TNF)-α21+ years oldAblationAccelerationAcuteAddressAdultAdult HumanAffectAge MonthsAnti-Hypertensive AgentsAnti-Hypertensive DrugsAnti-HypertensivesAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryBeta Proprotein Interleukin 1Body TissuesBone FormationCachectinCalcanean TendonCalcineurinCalcium Channel BlockersCalcium Channel Blocking DrugsCaringCausalityCell BodyCell Communication and SignalingCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCellsCellular MechanotransductionCellular ProliferationChondrocytesChronicClinicalClinical DataClinical TrialsDataData BasesDatabasesDevelopmentDiseaseDisorderDrug PrescribingDrug PrescriptionsDrug TherapyDrugsDysfunctionEarly identificationEctopic OssificationEtiologyExogenous Calcium AntagonistsExogenous Calcium BlockadersExogenous Calcium InhibitorsFDA approvedFiberFibroblastsFunctional disorderFutureGeneralized GrowthGeneticGrowthHealthHeterotopic OssificationHistologyHumanHypertensionHypotensive AgentHypotensive DrugsIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1βImageImmobilizationImmunoblottingImmunofluorescenceImmunofluorescence ImmunologicImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIncidenceInflammationInflammatoryInjectionsInjuryInterleukin 1betaInterleukin-1 betaInterleukin-1βIntracellular Communication and SignalingInvestigationL-Type Calcium ChannelsL-Type VDCCL-Type Voltage-Dependent Calcium ChannelsLacZLacZ GenesLeadLinkLong-Lasting Calcium ChannelsMacrophage-Derived TNFMechanical Signal TransductionMechanical StimulationMechanicsMechanosensory TransductionMediatingMediatorMedicationMiceMice MammalsModelingModern ManMolecularMonitorMonocyte-Derived TNFMurineMusNuclearOperative ProceduresOperative Surgical ProceduresOsteoblastsOsteogenesisPP2BPainPainfulPathogenesisPathologicPathologic OssificationPathological OssificationPathologyPatientsPb elementPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhenotypePhysiatric ProcedurePhysical Medicine ProcedurePhysical TherapeuticsPhysical therapyPhysiologicPhysiologicalPhysiopathologyPhysiotherapyPreinterleukin 1 BetaProtein Phosphatase-2BRecoveryRecovery of FunctionReporterReproducibilityRoleSedentary behaviorSedentary life-styleSeriesSignal TransductionSignal Transduction SystemsSignalingSurgicalSurgical InterventionsSurgical ProcedureTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTamoxifenTendinitisTendinopathyTendon structureTendonitisTendonsTestingTherapeuticTissue GrowthTissuesTransgenic MiceTransgenic OrganismsTumor Necrosis FactorTumor Necrosis Factor-alphaUpregulationVascular Hypertensive DiseaseVascular Hypertensive DisorderWestern BlottingWestern ImmunoblottingWild Type MouseWorkachilles tendonadulthoodanti-hypertensionbiological signal transductionbone tissue formationcalcium antagonistcausationchannel blockerscytokinedata basedevelopmentaldisabilitydisease causationdrug interventiondrug treatmentdrug/agenteconomic costefficacy studyfunctional recoverygain of functionheavy metal Pbheavy metal leadhigh blood pressurehuman diseasehuman tissuehyperpiesiahyperpiesishypertensivehypertensive diseasehypertensive disorderimaginginjuredinjuriesinjury responseloss of functionmechanicmechanicalmechanical loadmechanosensingmechanotransductionmedication prescriptionmouse modelmurine modelmutantnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetontogenyorthopedic freezingosteoblast cell differentiationosteoblast differentiationosteoblastic differentiationpain reliefpathophysiologypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspopulation healthpostnatalprescribed medicationpreventpreventingprophylacticprotein blottingrandomized, clinical trialsrelieve painresponseresponse to injurysedentary lifestylesocial rolesocio-economicsocio-economicallysocioeconomicallysocioeconomicsstandard of caresurgerytransgenicvoltagewildtype mouse
Description preview
PROJECT SUMMARY
The tensile-bearing Achilles tendon is highly prone to acute- or overuse-induced injuries that lead to chronic
tendon degeneration and heterotopic ossification (HO) called tendinopathy. Achilles tendinopathy is often
associated with pain and disability with high socio-economic costs. The current standard of care for treating…
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