grant
Investigating the Role of Tanycyte Barriers at the Circumventricular Organs in Health and Neuroinflammation.
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 3 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20262-photonAcuteAddressAffectAntigen PresentationAntigensArcuate NucleusAutoimmuneAutoregulationBiologyBlood - brain barrier anatomyBlood CirculationBlood VesselsBlood-Brain BarrierBloodstreamBody TissuesBrainBrain Nervous SystemBrain regionCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCNS Nervous SystemCNS autoimmunityCell BodyCell Communication and SignalingCell SignalingCellsCentral Nervous SystemCerebrospinal FluidCessation of lifeChronicClass I GenesCommunicationDeathDegenerative Neurologic DisordersDetectionDiseaseDisorderDisseminated SclerosisDysfunctionEAEEncephalonEndocrine Gland SecretionEnvironmentExperimental Allergic EncephalitisExperimental Allergic EncephalomyelitisExperimental Autoimmune EncephalitisExperimental Autoimmune EncephalomyelitisFe elementFe metabolismFoundationsFunctional disorderGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessGoalsHPA axisHealthHemato-Encephalic BarrierHistologyHomeostasisHormonesHungerHypothalamic dysfunctionHypothalamic structureHypothalamusImageImmuneImmune SurveillanceImmune systemImmunesImmunologic SurveillanceImmunosurveillanceInfiltrationInflammationInflammatoryInfundibular NucleusInnate Immune ResponseIntracellular Communication and SignalingIonsIronLinkMHC Class IMHC Class I GenesMaintenanceMediatingMetabolicMetabolic DiseasesMetabolic DisorderMetabolic dysfunctionMetabolic hormoneMolecularMultiple SclerosisNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeuraxisNeurodegenerative DiseasesNeurodegenerative DisordersNeuroendocrineNeuroendocrine SystemNeurologic Degenerative ConditionsNeuron DegenerationNeurosecretory SystemsOccluding JunctionsOrganOrganism-Level ProcessOrganismal ProcessOsmoregulationPathway interactionsPeripheralPermeabilityPhysiologic ProcessesPhysiological HomeostasisPhysiological ProcessesPhysiopathologyPlayPositionPositioning AttributePredispositionProcessPropertyProteinsRegulationReproductionRoleSepsisSignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingStimulusStressStructure of nucleus infundibularis hypothalamiSusceptibilitySystemSystemic infectionT-CellsT-LymphocyteT8 CellsT8 LymphocytesTherapeutic InterventionThesaurismosisTight JunctionsTissuesToxinUpregulationVascular PermeabilitiesWorkZonula Occludensadaptive immunityautoimmune encephalomyelitisbasebasesbiological signal transductionbloodbrain barriercell typecentral nervous system autoimmunitycerebral spinal fluidcerebrospinal fluid flowdegenerative diseases of motor and sensory neuronsdegenerative neurological diseaseshypothalamichypothalamic-pituitary-adrenal (HPA) axishypothalamic-pituitary-adrenal axishypothalmus-pituitary-adrenal axisimagingimmunogeninsightinsular sclerosisintervention therapyintra-vital microscopyintravital microscopyiron metabolismlenslensesmedian eminencemetabolism disordermouse modelmurine modelneuralneural degenerationneural inflammationneurodegenerationneurodegenerativeneurodegenerative illnessneuroinflammationneuroinflammatoryneurological degenerationneuronal degenerationnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathophysiologypathwayresponsesNuc-Seqsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolespinal fluidsystemic inflammationsystemic inflammatory responsethymus derived lymphocytetranscriptomicstwo-photonvascular
Description preview
Project Summary
Circumventricular organs (CVOs) are specialized brain regions with unique vascular properties, lacking
the classical blood-brain barrier (BBB), to facilitate rapid communication between the brain and
periphery. Among these, the median eminence (ME) plays a central role in regulating vital
neuroendocrine processes such as hunger,…
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