grant
Investigating the role of peripheral nerve damage in chronic Toxoplasma infection
Organization STATE UNIVERSITY OF NEW YORK AT BUFFALOLocation AMHERST, UNITED STATESPosted 18 Dec 2025Deadline 17 Dec 2028
NIHUS FederalResearch GrantFY2025AcuteAddressBody TissuesBrainBrain Nervous SystemCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCNS Nervous SystemCatsCats MammalsCell BodyCellsCentral Nervous SystemChronicCommunicationCystDataDomestic CatsElectrophysiologyElectrophysiology (science)EncephalonFamily FelidaeFelidaeFelidsFeline SpeciesFelis catusFelis domesticaFelis domesticusFelis sylvestris catusFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGoalsHealth systemImageImage CytometryImmuneImmune infiltratesImmune responseImmune systemImmunesImpairmentIn VitroInfectionInflammationInflammatoryInflammatory ResponseInvestigationKineticsLife CycleLife Cycle StagesLong-term infectionLyticMacrophageMediatingMetabolicMiceMice MammalsMorphologyMotorMotor CellMotor NeuronsMouse StrainsMurineMusMuscleMuscle TissueMyoneural JunctionMφNerveNeuraxisNeuromuscular JunctionNeurophysiology / ElectrophysiologyParasite ControlParasitesParasitic infectionPathogenicityPathologicPathologyPeripheral NervesPeripheral Nervous SystemPhasePopulationPredatory BehaviorPredispositionProductionRegulatory T-LymphocyteResearch TrainingResistanceRodentRodentiaRodents MammalsRoleSiteSkeletal MuscleSmall IntestinesStructureSusceptibilitySynapsesSynapticSystemT gondiiT gondii infectionT. gondiiT. gondii infectionT4 CellsT4 LymphocytesTestingTimeTissuesToxoplasmaToxoplasma gondiiToxoplasma gondii InfectionToxoplasmosisTregTropismVoluntary MuscleWorkcatscell typechronic infectionelectrophysiologicalfelineflow cytophotometryfunctional losshost responseimagingimmune cell infiltrateimmune system responseimmunogenicimmunoresponseinfected with parasitesinsightlife courseloss of functionmotoneuronmuscle fiber repairmuscle repairmuscle tissue repairmuscularmuscular repairneuromuscular transmissionparasite infectionperipheral nerve damagepersistent infectionpharmacologicpredationregulatory T-cellsresistantsmall bowelsocial rolesynapsetissue tropismtrend
Description preview
Project Summary
Toxoplasma gondii is a highly successful intracellular parasite estimated to infect up to a third of the world’s
population. T. gondii establishes a chronic infection forming intracellular cysts largely in the central nervous
system (CNS) and skeletal muscle, associated with chronic inflammation and critically, a loss of motor…
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