grant
Investigating the role of human-specific 3D genome conformation in the context of brain development and disease
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 1 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY20250-11 years old3-D3-Dimensional3C-based approach3C-based assay3C-based method3C-based strategy3C-based technique3C-based technology3DASDApesAssayAutismAutistic DisorderAutomobile DrivingBioassayBiological AssayBody TissuesBrainBrain Nervous SystemCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChildChild YouthChildren (0-21)ChimpChimpanzeeChromatinClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCognitiveComplementComplement ProteinsComputational toolkitConvNetDataDevelopmentDevelopmental DelayDevelopmental Delay DisordersDifferential Gene ExpressionDiseaseDisorderEarly Infantile AutismElectrophysiologyElectrophysiology (science)EncephalonEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvolutionExpression SignatureGene DuplicationGene ExpressionGene Expression ProfileGenesGenetics-MutagenesisGenomeGenomic approachGenomicsGlutamatesHi-CHistonesHominidaeHominidsHumanHuman GenomeIn VitroIndividualInduced pluripotent stem cell derived human neuronInfantile AutismInvestigationKanner's SyndromeKnock-inKnock-outKnockoutKnowledgeL-GlutamateLinkLiverM mulattaM. mulattaMacaca mulattaMacaca rhesusMeasuresMissionModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular StereochemistryMorphologyMutagenesisMutagenesis Molecular BiologyNational Institutes of HealthNerve CellsNerve UnitNeural CellNeural DevelopmentNeural Stem CellNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuronsNeurophysiology / ElectrophysiologyNuclearOrang-utanOrangutanOrganism-Level ProcessOrganismal ProcessPathologyPatientsPhasePhenotypePhysiologicPhysiologic ProcessesPhysiologicalPhysiological ProcessesPlayPongidaePongo pygmaeusPrimatesPrimates MammalsProcessProliferatingPropertyPublic HealthRNA SeqRNA sequencingRNAseqRecurrenceRecurrentRegulationResearchResolutionRhesusRhesus MacaqueRhesus MonkeyRodentRodentiaRodents MammalsRoleSchizophreniaSchizophrenic DisordersSpecific Child Development DisordersStructureSubcellular ProcessSynapsesSynapticTechniquesTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTissuesUnited States National Institutes of HealthValidationautism spectral disorderautism spectrum disorderautistic spectrum disorderbrain cellchromatin conformation capturechromosome capturechromosome conformation capturecohesincomparativecomplementationcomputational toolboxcomputational toolscomputational toolsetcomputerized toolsconformationconformationalconformational stateconformationallyconformationsconvolutional networkconvolutional neural netsconvolutional neural networkdementia praecoxdensitydevelopmentaldifferentiation protocoldrivingelectrophysiologicalepigeneticallygene expression patterngene expression signaturegenome editinggenomic editinggenomic effortgenomic strategyglutamatergicgreat apehepatic body systemhepatic organ systemhiPSChiPSC-derived neuronshuman iPShuman iPSChuman iPSC-derived sensory neuronhuman induced pluripotent cellhuman induced pluripotent stem cell derived sensory neuronhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshuman whole genomeiPSiPSCiPSC-derived human neuroniPSCsin silicoin vivoinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinducible pluripotent stem cell derived human neuroninducible pluripotent stem cell derived human sensory neuroninsightkidsknockinlymphoblastmolecular phenotypemulti-modalitymultimodalityneglectnerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurodevelopmentneurodevelopmental diseaseneurogenic progenitorsneurogenic stem cellneuron developmentneuron progenitorsneuronalneuronal developmentneuronal progenitorneuronal progenitor cellsneuronal stem cellsneurons differentiated from human induced pluripotent stem cellsneuroprogenitornovelprogenitor and neural stem cellspromoterpromotorresolutionsschizophrenicsocial rolespecies differencesynapsethree dimensionaltraittranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtranscriptomicsvalidationsyoungster
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PROJECT SUMMARY
The human brain has undergone many specializations (e.g., increased synapse density) resulting in
unmatched cognitive complexity, as well as increased vulnerability to neurodevelopmental disorders, such as
autism. Differences in gene expression are responsible for most human-specific brain specializations, and
comparative…
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