grant
Investigating the role of FOXL2 during urethra closure
Organization UNIVERSITY OF MISSOURI-COLUMBIALocation COLUMBIA, UNITED STATESPosted 1 Feb 2026Deadline 30 Nov 2030
NIHUS FederalResearch GrantFY20260-4 weeks oldAblationActivities of Daily LivingActivities of everyday lifeAddressAffectAndrogen ReceptorAndrogenic AgentsAndrogenic CompoundsAndrogensAssayBasal Transcription FactorBasal transcription factor genesBasement membraneBindingBioassayBiological AssayBirth DefectsCausalityCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell FunctionCell PhysiologyCell ProcessCell SignalingCell-Extracellular MatrixCellsCellular FunctionCellular PhysiologyCellular ProcessChromatinCommunicationCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationDNA mutationDataDefectDevelopmentECMEnzyme GeneEnzymesEpitheliumEtiologyExtracellular MatrixFOXL2FOXL2 geneForkhead Transcription Factor FOXL2General Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ChangeGenetic defectGenetic mutationGoalsHumanHypospadiasIntracellular Communication and SignalingInvadedKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLeadMale UrethraMale urethral structureMesenchymalMesenchymasMesenchymeMiceMice MammalsModelingModern ManModificationMolecularMolecular InteractionMurineMusMutationNewborn InfantNewbornsNull MouseOperative ProceduresOperative Surgical ProceduresPFRKPb elementPhenotypePituitary Forkhead Factor, Mouse, Homolog ofPopulationPreventiveProcessPublicationsRegulationResearchRoleSCmRNAseqScientific PublicationSignal TransductionSignal Transduction SystemsSignalingSingle cell mRNA seqSpecific qualifier valueSpecifiedSubcellular ProcessSurgicalSurgical InterventionsSurgical ProcedureTechnical ExpertiseTesticlesTestingTestisTestosteroneTherapeutic AndrogenTherapeutic TestosteroneTimeTrans-TestosteroneTranscription Factor Proto-OncogeneTranscription factor genesUnited StatesUrethrabiological signal transductionboyscausationcell typecellular differentiationdaily living functiondaily living functionalitydevelopmentaldisease causationfetalfork head proteinforkhead proteinforkhead transcription factorsfunctional abilityfunctional capacitygenome mutationheavy metal Pbheavy metal leadmalformationmouse modelmurine modelnewborn childnewborn childrennovelpenile urethrapenisreceptor bindingreceptor boundresponsesingle cell mRNA sequencingsocial rolesurgerytechnical skillstranscription factorurethral
Description preview
Project Summary
Hypospadias is one of the most common birth defects in the world, affecting nearly 1% of newborn boys.
Hypospadias is abnormal urethra closure, where the urethra exits ventrally along the shaft of the penis, and not
the tip. Although hypospadias is common, the origin of 70% of urethral closure defects remains unknown.
During…
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