grant
Investigating the Role of Extracellular Matrix in Down Syndrome Associated Cardiac Phenotypes.
Organization MASSACHUSETTS INSTITUTE OF TECHNOLOGYLocation CAMBRIDGE, UNITED STATESPosted 1 Feb 2025Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAdhesion MoleculeAffectAgingArchitectureBiologyBiomedical EngineeringBirthBlocking AntibodiesBody TissuesBrainBrain Nervous SystemCancersCardiacCardiac Muscle CellsCardiac MyocytesCardiac defectCardiac developmentCardiocyteCell AdhesionCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCell CommunicationCell Communication and SignalingCell CycleCell Division CycleCell InteractionCell IsolationCell LineCell SegregationCell SeparationCell Separation TechnologyCell SignalingCell-Cell AdhesionCell-Extracellular MatrixCell-to-Cell InteractionCellLineCellsCellular AdhesionCellular MatrixChromatinChromosome 21CodeCoding SystemCollaborationsCollagen Type VIComplexCongenital Cardiac DefectsCongenital Heart DefectsContact InhibitionCreativenessCritical PathsCritical PathwaysCytoskeletal ModelingCytoskeletal OrganizationCytoskeletal Organization ProcessCytoskeletal ReorganizationCytoskeletal SystemCytoskeletonDataDepositDepositionDevelopmentDiseaseDisorderDown SyndromeECMEncephalonEngineering / ArchitectureEnvironmentExpression SignatureExtracellular MatrixFellowshipFibrosisFoundationsGene ExpressionGene Expression ProfileGene TranscriptionGenesGenetic TranscriptionGenomeHeartHeart Muscle CellsHeart myocyteHumanHuman ChromosomesIncidenceIndividuals with down syndromeInfantInfant MortalityInfant Mortality TotalIntegrinsIntegrins Extracellular MatrixIntima CollagenIntracellular Communication and SignalingInvestigatorsKnowledgeLamin ALamin Type ALaminsLangdon Down syndromeLeadMalignant NeoplasmsMalignant TumorMapsMassachusettsMentorshipMiceMice MammalsModalityModelingModern ManMolecularMongolismMorbidityMorphologyMurineMusMyocardiumNeural DevelopmentNuclearOutcomeParturitionPathologyPathway interactionsPb elementPersonsPhenotypeRNA ExpressionReceptor ProteinRegulationReporterResearchResearch PersonnelResearchersRoleScanning Electron MicroscopySignal TransductionSignal Transduction SystemsSignalingStrains Cell LinesStructureSystemTechnologyTestingTherapeuticTimeTissuesTrainingTranscriptionTrisomy 21Type V IF ProteinType VI (Intima) CollagenWorkage associatedage correlatedage dependentage linkedage relatedage specificautosomebio-engineeredbio-engineersbioengineeringbiological engineeringbiological signal transductioncardiac musclecardiac myocytes differentiated from induced pluripotent stem cellcardiogenesiscardiomyocytecell adhesion proteincell sortingchromosome 21 trisomychromosome 21 trisomy syndromecollagen 6collagen Type 6collagen VIcongenital acromicria syndromecreativitycultured cell linedeath among infantsdeath in first year of lifedeath in infancydeath in infantsdevelopmentaldown syndrome individualsdown syndrome patientsexperiencegene expression patterngene expression signatureheart defectheart developmentheart formationheart muscleheavy metal Pbheavy metal leadhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsiPSiPS cell derived cardiomyocytesiPSCiPSC derived cardiomyocytesiPSCsinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinduced pluripotent stem cell derived cardiac myocytesinduced pluripotent stem cell derived cardiomyocytesinducible pluripotent cellinducible pluripotent stem cellinducible pluripotent stem cell derived cardiac myocytesinducible pluripotent stem cells derived cardiomyocytesinfant deathinfant demiseinfantile deathinsightinterdisciplinary approachintracellular skeletonlenslensesmalignancymechanical cuemechanical forcemechanical loadmechanical signalmorbus Downmortality in infantsmouse modelmultidisciplinary approachmurine modelneoplasm/cancerneurodevelopmentnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoverexpressoverexpressionpathwaypatients with down syndromepeople with down syndromeprogramspseudohypertrophic progressive muscular dystrophyreceptorresponseseptal defectseptum defectskillssmall moleculesocial rolethree dimensionaltranscriptional profiletranscriptional signaturetrisomy 21 syndrome
Description preview
PROJECT SUMMARY
Congenital heart defects (CHD) affect ~1% of all births and are the leading cause of morbidity and mortality in
infants. Notably, over 50% of Down Syndrome (DS) infants, the most prevalent autosomal abnormality caused
by trisomy 21 (T21), are born with a CHD, with septal defects most common. The pathways that contribute to
cardiac…
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