grant
Investigating the role of early postnatal neuromodulation in cerebellar development
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20260-11 years old4-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAD/HDADHDASDAdverse ExperienceAdverse eventAffectiveAminalonAminaloneAmmon HornAnatomic SitesAnatomic structuresAnatomyAttention deficit hyperactivity disorderAutismAutistic DisorderBehaviorBehavioralBirthBrainBrain Nervous SystemCalcium-Binding ProteinsCare GiversCaregiversCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCerebellar CortexCerebellumCerebrospinal FluidChildChild YouthChildren (0-21)CognitionCognitiveConnector NeuronCornu AmmonisDataDevelopmentDiagnosisDiscipline of NursingEarly Infantile AutismElectrophysiologyElectrophysiology (science)EmotionsEncephalonEndocrine Gland SecretionEnvironmental FactorEnvironmental Risk FactorEventExposure toFutureGABAGene CombinationsGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneticGoalsHippocampusHormonesIn VitroInfantInfantile AutismIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronInterruptionIntracellular Communication and SignalingInvestigationKanner's SyndromeKnowledgeLabelLactationLife ExperienceLinkLocationMeasuresMessenger RNAMiceMice MammalsMolecularMorphologyMothersMotor SkillsMurineMusNeonatalNerve CellsNerve UnitNeural CellNeural TransmissionNeurocyteNeurodevelopmental DisorderNeurohormonesNeurological Development DisorderNeuronsNeurophysiology / ElectrophysiologyNursingNursing FieldNursing ProfessionOcytocinOxytocinOxytocin ReceptorParturitionParvalbuminsPatientsPerinatalPeripartumPhysiologicPhysiologicalPredispositionPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderProcessPurkinje CellsPurkinje's CorpusclesReceptor ActivationReceptor ProteinReceptor SignalingRecombinant OxytocinResearchRiskRisk FactorsRisk-associated variantRoleShapesSignal TransductionSignal Transduction SystemsSignalingStressSubcellular ProcessSusceptibilitySynapsesSynapticSynaptic TransmissionSynaptic plasticityTestingTimeTranscript Expression AnalysesTranscript Expression AnalysisUnited StatesVascularizationWorkanalyze gene expressionautism spectral disorderautism spectrum disorderautistic spectrum disorderbehavior phenotypebehavioral phenotypingbiological signal transductioncalbindincell typecerebellar Purkinje cellcerebral spinal fluiddevelopmentalelectrophysiologicalenvironmental riskgamma-Aminobutyric Acidgene expression analysisgene expression assaygenetic approachgenetic strategyhigh riskhippocampalinsightkidslactatinglactationallife spanlifespanmRNAmaladaptive behaviormaternal separationmotor abilitymotor behaviormouse modelmurine modelneglectneural controlneural regulationneurodevelopmental diseaseneuroendocrine hormonesneurohormonalneuromodulationneuromodulatoryneuronalneuroregulationnew approachesnovel approachesnovel strategiesnovel strategypost-natal developmentpostnatalpostnatal developmentprogenitorrate of changereceptorreceptor expressionresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantsocial attachmentsocial bondingsocial communicationsocial rolespinal fluidsynapsetranscriptional profilingtranscriptome profilingtranscriptomic profilingtranscriptomicsyoungsterγ-Aminobutyric Acid
Description preview
Abstract
This study seeks to elucidate the impact of early postnatal oxytocin signaling on cerebellar
development and function. The cerebellum shapes motor behavior, cognition, and emotion and, in
consequence, its functional disruption during early development is one of the highest risk factors for
neurodevelopmental disorders. Due to its…
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