grant
Investigating the role of dorsal raphe nucleus enkephalin neurons in motivational and affective behaviors during chronic pain
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY202621+ years oldAbsence of pain sensationAbsence of sensibility to painAcuteAcute PainAcutely painfulAdultAdult HumanAffectAffectiveAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnimalsAnodynesAntinociceptive AgentsAntinociceptive DrugsAnxietyApplications GrantsAreaBehaviorBehavioralBehavioral AssayBiologicalBloodBlood Reticuloendothelial SystemBrainBrain Nervous SystemBrain regionCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell Communication and SignalingCell NucleusCell SignalingChronicClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyColorCommunitiesComplexCoupledDREADDsDataDevelopmentDiseaseDisorderDorsalDysfunctionEmotionalEmotionsEncephalonEndoscopyEnkephalinsEpidemicFeels no painFunctional disorderGoalsGrant ProposalsHumanIndividualIntracellular Communication and SignalingInvestigatorsJournalsLabelLearningLigandsMagazineMental DepressionMesencephalic Central GrayMesencephalonMiceMice MammalsMid-brainMidbrainMidbrain Central GrayMidbrain structureModern ManMonitorMotivationMurineMusNRSANational Research Service AwardsNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeuropathyNeurosciencesNo sensitivity to painNociceptionNucleusOdorsOpiate PeptidesOpiatesOpioidOpioid PeptidePainPainfulPathologicPatternPeptidesPeriaqueductal GrayPeripheralPermeabilityPhenotypePhotonsPhysiopathologyPopulationProcessPublicationsResearchResearch PersonnelResearchersRewardsRoleSaccharoseSalineSaline SolutionScientific PublicationScientistSelf AdministeredSelf AdministrationSignal TransductionSignal Transduction SystemsSignalingSiteSpinalSucroseSystemTechnologyTherapeuticTherapeutic InterventionTimeTrainingUnited StatesUniversitiesViralVirusWashingtonWorkWritingadulthoodallodyniaanalgesiaannulus of the aqueductanxiety-like behaviorbehavior testbehavioral testbiologicbiological signal transductioncalcium indicatorchronic painco-morbidco-morbiditycomorbidityconditioned place preferenceconferenceconventiondepressiondesigner receptors exclusively activated by designer drugsdevelopmentaldorsal raphe nucleusendogenous opiateendogenous opioidsendoscopic imagingexperienceexperimentexperimental researchexperimental studyexperimentsfluorophorein vivoinsightintervention therapyknock-downknockdownmidbrain central gray substancemood regulationmotivated behaviornerve injuryneuralneural circuitneural circuitryneural injuryneurochemicalneurochemistryneurocircuitryneuronalneuropathicneuropathic painnext generationnociceptivenovelpain behaviorpain catastrophizingpain killerpain medicationpain reliefpain relieverpainful neuropathypainkillerpathophysiologyperiaqueductal gray matterplace conditioningpre-proenkephalinprepro-enkephalinpreproenkephalinpro-enkephalinproenkephalinredshiftrelieve painresponsesensory mechanismside effectskillssocial rolespared nervespontaneous painsuicidal risksuicide risksummitsymposiasymposiumsynaptic circuitsynaptic circuitrytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic evaluationtherapeutic testingtraining opportunity
Description preview
PROJECT SUMMARY
The primary goal of this NRSA F32 proposal is to determine the contribution of endogenous opioids in dorsal
raphe nucleus to motivational and affective dysregulation during chronic pain. Chronic pain is a complex disease
state which is associated with comorbidities such as depression, anxiety, and increased risk of suicide.…
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