grant
Investigating the role and therapeutic potential of the alpha5beta1 integrin in risk factors for COVID-19-associated cognitive impairment
Organization TULANE UNIVERSITY OF LOUISIANALocation NEW ORLEANS, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20262019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV variant2019-nCoV variant forms2019-nCoV variant strainsACE2AccelerationAddressAmentiaAnimalsApoplexyArg-Gly-AspArginine-Glycine-Aspartic Acid Cell Adhesion DomainArteriosclerotic DementiaBALB C MouseBALB/cBBB disruptionBand 2 ProteinBilateralBindingBlood - brain barrier anatomyBlood SerumBlood VesselsBlood-Brain BarrierBrainBrain IschemiaBrain Nervous SystemBrain PathologyBrain VascularBrain Vascular AccidentCOVID associated morbidityCOVID disease severityCOVID incidenceCOVID induced morbidityCOVID morbidityCOVID prevalenceCOVID related morbidityCOVID severityCOVID-19COVID-19 associated morbidityCOVID-19 case incidenceCOVID-19 disease incidenceCOVID-19 disease prevalenceCOVID-19 disease severityCOVID-19 incidenceCOVID-19 induced morbidityCOVID-19 infectionCOVID-19 morbidityCOVID-19 prevalenceCOVID-19 related morbidityCOVID-19 related riskCOVID-19 riskCOVID-19 risk factorCOVID-19 severityCOVID-19 variantCOVID-19 variant formsCOVID-19 variant strainsCOVID-19 virusCOVID-19 virus infectionCOVID19 disease severityCOVID19 infectionCOVID19 severityCOVID19 virusCV-19Carotid Artery NarrowingCarotid Artery StenosisCarotid StenosisCell BodyCell Communication and SignalingCell Culture TechniquesCell SignalingCell membraneCell surfaceCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular CirculationCerebrovascular StrokeCerebrovascular systemChemotactic CytokinesChronicClinical ResearchClinical StudyCoV-2CoV2CognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplexContracting OpportunitiesContractsCoronavirus Infectious Disease 2019Cytoplasmic DomainCytoplasmic MembraneCytoplasmic TailDataDementiaDisturbance in cognitionDysfunctionElderlyEncephalonEndothelial CellsExposure toFemaleFunctional disorderGelHemato-Encephalic BarrierHomologous Chemotactic CytokinesHypoxiaHypoxicImmunofluorescenceImmunofluorescence ImmunologicImpaired cognitionIn VitroInbred BALB C MiceIncidenceIndividualInfectionIntegrin InhibitionIntegrin alpha-5 beta-1Integrin alpha5beta1Integrin α5β1IntegrinsIntegrins Extracellular MatrixIntercrinesInterphase CellIntracellular Communication and SignalingIschemic EncephalopathyLabelLinkMeasurementMiceMice MammalsModelingMolecular InteractionMorbidityMurineMusNeurocognitiveNon-dividing CellNondividing CellOutcomeOxygen DeficiencyPathogenicityPathologicPatientsPhysiopathologyPlasma MembranePlatelet Glycoprotein Ic/IIaPlayPredispositionProductivityProteinsRGD (sequence)RGD Cell Adhesion DomainRGD DomainRGD MotifRGD Tripeptide SequenceRGD peptideRGD tripeptideReceptor InhibitionReceptor ProteinResting CellRiskRoleSARS VirusSARS corona virusSARS corona virus 2SARS coronavirusSARS-Associated CoronavirusSARS-CO-V2SARS-COVID-2SARS-CoVSARS-CoV-1SARS-CoV-2SARS-CoV-2 disease severitySARS-CoV-2 incidenceSARS-CoV-2 infectionSARS-CoV-2 infection prevalenceSARS-CoV-2 inhibitorSARS-CoV-2 prevalenceSARS-CoV-2 severitySARS-CoV-2 variantSARS-CoV-2 variant formsSARS-CoV-2 variant strainsSARS-CoV2SARS-CoV2 infectionSARS-Related CoronavirusSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SIS cytokinesSerumSevere Acute Respiratory CoronavirusSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome VirusSevere Acute Respiratory Syndrome corona virusSevere Acute Respiratory Syndrome coronavirusSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 inhibitorSevere acute respiratory syndrome related corona virus 2Signal TransductionSignal Transduction SystemsSignalingStrokeSurfaceSusceptibilityTalinTherapeuticTherapeutic StudiesTherapy ResearchUpregulationVLA-5VLA-5 ReceptorsVascular DementiaViralViral ReceptorVirusVirus ReceptorsWuhan coronavirusacute COVID-19acute SARS-CoV-2 infectionacute phase of COVID-19acute phase of SARS-CoV-2 infectionadvanced ageafter COVID-19 infectionafter SARS-CoV-2 infectionafter SARS-CoV2 infectionafter infection by SARS-CoV-2after severe acute respiratory distress syndrome CoV-2 infectionafter strokeage associatedage correlatedage dependentage linkedage relatedage specificagedaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging populationangiotensin converting enzyme 2angiotensin converting enzyme IIarginyl-glycyl-aspartic acidbasebasesbehavior testbehavioral testbiological signal transductionblock SARS-CoV-2block severe acute respiratory syndrome coronavirus 2blood flow in brainblood vessels in the brainblood-brain barrier disruptionbloodbrain barrierbloodbrain barrier disruptionbrain attackbrain blood circulationbrain blood flowbrain blood vesselsbrain vascular pathologybrain vascular pathophysiologybrain vasculaturecell culturecell culturescerebral angiopathycerebral blood flowcerebral blood vesselcerebral circulationcerebral vascularcerebral vascular accidentcerebral vascular pathologycerebral vasculaturecerebral vasculopathycerebro-vascularcerebrocirculationcerebrovascularcerebrovascular abnormalitycerebrovascular accidentcerebrovascular blood flowcerebrovascular contributions to dementiacerebrovascular defectcerebrovascular disease pathologycerebrovascular pathologycerebrovascular pathophysiologycerebrovascular vesselscerebrovasculaturecerebrovasculopathychemoattractant cytokinechemokineclinical validationco-morbidco-morbiditycognitive dysfunctioncognitive losscomorbiditycoronavirus disease 2019coronavirus disease 2019 associated morbiditycoronavirus disease 2019 disease severitycoronavirus disease 2019 induced morbiditycoronavirus disease 2019 infectioncoronavirus disease 2019 morbiditycoronavirus disease 2019 related morbiditycoronavirus disease 2019 riskcoronavirus disease 2019 risk factorcoronavirus disease 2019 severitycoronavirus disease 2019 variantcoronavirus disease 2019 variant formscoronavirus disease 2019 variant strainscoronavirus disease 2019 viruscoronavirus disease associated morbiditycoronavirus disease induced morbiditycoronavirus disease morbiditycoronavirus disease related morbiditycoronavirus disease severitycoronavirus disease-19coronavirus disease-19 viruscoronavirus infectious disease-19cytokineeffective therapyeffective treatmentfollowing COVID-19 infectionfollowing SARS-CoV-2 infectionfollowing SARS-CoV2 infectionfollowing infection by SARS-CoV-2following severe acute respiratory distress syndrome CoV-2 infectionfunctional outcomesgeriatrichCoV19improvedin vivoincidence rates of SARS-CoV-2 infectionincident cases of SARS-CoV-2infected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2infection with SARS-CoV-2inhibit SARS-CoV-2inhibit severe acute respiratory syndrome coronavirus 2inhibitorlife-threatening COVIDlife-threatening COVID-19life-threatening SARS-CoV-2life-threatening coronavirus diseaselife-threatening coronavirus disease 2019life-threatening severe acute respiratory syndrome coronavirus 2malemonolayermortalitynCoV2neural inflammationneuroinflammationneuroinflammatorynon-dementednondementednovelpathophysiologyplasmalemmapopulation agingpost SARS-CoV-2 infectionpost strokepost-COVIDpost-COVID-19post-coronavirus disease 2019poststrokepreventpreventingprevious COVID-19 infectionprevious SARS-CoV-2 infectionprevious SARS-CoV2 infectionprevious severe acute respiratory distress syndrome CoV-2 infectionprior COVID-19 infectionprior SARS-CoV-2 infectionprior SARS-CoV2 infectionprior severe acute respiratory distress syndrome CoV-2 infectionreceptorreceptor mediated endocytosisrho G-Proteinsrho GTP-Binding Proteinsrho GTPasesrho Protein P21rho Small GTP-Binding Proteinsrisk associated with COVID-19risk factor associated with COVID-19risk factor related to COVID-19risk related to COVID-19senior citizenserious COVIDserious COVID-19serious SARS-CoV-2serious coronavirus diseaseserious coronavirus disease 2019serious severe acute respiratory syndrome coronavirus 2severe COVIDsevere COVID-19severe COVID19severe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 disease severitysevere acute respiratory syndrome coronavirus 2 severitysevere acute respiratory syndrome coronavirus 2 variantsevere acute respiratory syndrome coronavirus 2 variant formssevere acute respiratory syndrome coronavirus 2 variant strainssevere acute respiratory syndrome-CoVsevere coronavirus diseasesevere coronavirus disease 19severe coronavirus disease 2019severe severe acute respiratory syndrome coronavirus 2social rolespatial and temporalspatial temporalspatiotemporalstrokedstrokessystemic inflammationsystemic inflammatory responsetheoriesvascularvascular contributions in dementiavascular contributions to dementiavascular related dementiawhite matter damageyounger age♀♂
Description preview
ABSTRACT
Rapidly emerging evidence has characterized the association between vascular dementia (VaD) and increased
COVID-19 incidence, morbidity, and post-COVID cognitive decline. We theorize that brain vascular pathology in
VaD and additional pathophysiologic features such as blood-brain barrier (BBB) disruption and reduced cerebral
blood flow…
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