grant
Investigating the RNA-Regulatory Activities of the RNA Exosome during Human Motor Neuron Differentiation
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 3 Jul 2025Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025Action PotentialsAffectBody TissuesCLIP-SeqCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCell Culture TechniquesCell DifferentiationCell Differentiation processCell LineCell LineageCellLineCellsClinicalClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCodeCoding SystemComplexDNA mutationDataDefectDevelopmentDiseaseDisorderEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEngineeringGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationHITS-CLIPHandHereditaryHigh-throughput sequencing of CLIP cDNA libraryHumanHuman FigureHuman bodyImmunoblottingIn VitroIndividualInheritedLeadLinkMaintenanceMeasuresMediatingMethodsMissense MutationModelingModern ManMonitorMorphologyMotorMotor CellMotor Neuron DiseaseMotor NeuronsMutationNTRK2NTRK2 geneNerve CellsNerve UnitNervous SystemNeural CellNeural DevelopmentNeural Stem CellNeurocyteNeurodevelopmental DisorderNeurologic Body SystemNeurologic Organ SystemNeurological Development DisorderNeuronal DifferentiationNeuronsNeuropathyNon-Polyadenylated RNAPathogenicityPathologicPb elementPhenotypePlayPontocerebellar hypoplasiaPost-Transcriptional ControlPost-Transcriptional RegulationPredispositionProcessProgenitor CellsProteinsRNARNA ExpressionRNA Gene ProbesRNA Gene ProductsRNA NucleasesRNA ProbesRNA SeqRNA sequencingRNAseqRNaseRegulationReportingResearchRibonuclease Family ProteinRibonucleasesRibonucleic AcidRoleSeveritiesSpinalStaining methodStainsStrains Cell LinesSusceptibilityTRKBTimeTissuesTranscriptTranscriptionTranscription ActivationTranscriptional ActivationVariantVariationWestern BlottingWestern ImmunoblottingYeastsbrain atrophycell culturecell culturescell typecellular differentiationcerebral atrophycortical atrophycrosslinking and immunoprecipitation sequencingcultured cell linedegenerative disorder of motor neuronsdevelopmentaldirected differentiationdisease causing variantdisease modeldisease-causing alleledisease-causing mutationdisorder modelexosomeexperimentexperimental researchexperimental studyexperimentsgenome mutationglobal gene expressionglobal transcription profilehandsheavy metal Pbheavy metal leadhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsinduced human pluripotent stem cellsinsightmRNA sequencingmRNA-seqmRNAseqmissense single nucleotide polymorphismmissense single nucleotide variantmissense variantmotoneuronmotor neuron developmentmulti-electrode arraysmultielectrode arraysmutantnerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurodevelopmentneurodevelopmental diseaseneurogenesisneurogenic progenitorsneurogenic stem cellneuron developmentneuron progenitorsneuronalneuronal developmentneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuropathicneuroprogenitornovelpathogenic allelepathogenic variantpluripotencypluripotent statepost-transcriptional gene regulationpostmitoticposttranscriptionalprenatalprogenitor and neural stem cellsprogenitor cell differentiationprogenitor cell maintenanceprogenitor cell modelprogenitor cell poolprogenitor cell populationprogenitor cell proliferationprogenitor differentiationprogenitor maintenanceprogenitor modelprogenitor poolprogenitor populationprogenitor proliferationprotein blottingself-renewself-renewalsocial rolestem and progenitor cell modelstem and progenitor cell populationstem and progenitor cell proliferationstem and progenitor differentiationstem cell based modelstem cell derived modelstem cell differentiationstem cell maintenancestem cell modelstem cell poolstem cell populationstem cell proliferationstem cellstranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicsunborn
Description preview
Project Summary:
Accurate stem cell differentiation requires precise gene regulation at both the transcriptional and post-
transcriptional levels. While the transcriptional activation networks governing cellular differentiation are well
characterized, the mechanisms by which post-transcriptional control of gene expression alters the transcriptome…
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