grant
Investigating the pro-regenerative potential of Pontin in the heart.
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2029
NIHUS FederalResearch GrantFY202521+ years oldATACATP phosphohydrolaseATPaseAdenosine TriphosphataseAdultAdult HumanAntimorphic mutationAzurophil Granule Protein 7B-Cell Translocation Gene 2BTG family, member 2BTG2BTG2 GeneBindingBiologicalBirthBrachydanio rerioC-ANCAC-ANCA AntigenCandidate Disease GeneCandidate GeneCardiacCardiac DiseasesCardiac DisordersCardiac Muscle CellsCardiac MyocytesCardiac developmentCardiac infarctionCardiocyteCause of DeathCell BodyCell CycleCell Cycle InhibitionCell Division CycleCell divisionCellsCessation of lifeChildhoodChromatinCicatrixDNA TherapyDanio rerioDataData SetDeathDevelopmentDifferential DisplayDominant NegativeDominant-Negative MutantDominant-Negative MutationDown-RegulationEFRACEjection FractionEmbryoEmbryonicEmbryonic HeartEpistasisEpistatic DeviationGene ExpressionGene Transfer ClinicalGeneHomologGeneralized GrowthGenesGeneticGenetic EpistasisGenetic InterventionGoalsGrowthHeartHeart DiseasesHeart InjuriesHeart Muscle CellsHeart myocyteHomologHomologous GeneHomologueHumanIntegrinsIntegrins Extracellular MatrixInteraction DeviationIschemic HeartIschemic Heart DiseaseIschemic myocardiumIsoformsKnock-outKnockoutKnowledgeLPTNLearningLeukocyte Proteinase 3Life ExpectancyLoxP-flanked alleleMammaliaMammalsMediatingMiceMice MammalsModern ManMolecularMolecular AnalysisMolecular InteractionMurineMusMyeloblastinMyocardialMyocardial InfarctMyocardial InfarctionMyocardial IschemiaMyocardiumN-proteinase 4NP-4NP4(3)Natural regenerationNeonatalNeutrophil Proteinase 4Neutrophil Serine ProteinasePC3 genePR-3ParturitionPathway interactionsProliferatingProtein IsoformsProteinase 3QOLQuality of lifeRNA SeqRNA sequencingRNAseqRecovery of FunctionRegenerationRegenerative capacityRegenerative responseRepressionResearchRoleSCM-1SCM-1aSCM1SCYC1ScarsTestingTherapeuticTissue GrowthValidationWegener AutoantigenWegener Granulomatosis AutoantigenXCL1XCL1 geneZebra DanioZebra FishZebrafishadulthoodattack victimbiologiccardiac infarctcardiac injurycardiac ischemiacardiac musclecardiac regenerationcardiac repaircardiogenesiscardiomyocytecoronary attackcoronary infarctcoronary infarctioncoronary ischemiacostdevelopmentaldifferential display techniqueembryo heartepistatic interactionepistatic relationshipfloxedfloxed allelefunctional recoverygene locusgene regulatory networkgene repair therapygene therapygene x gene interactiongene-based therapygenetic approachgenetic epistasesgenetic locusgenetic strategygenetic therapygenomic locationgenomic locusgenomic therapyheart attackheart developmentheart disorderheart formationheart infarctheart infarctionheart ischemiaheart muscleheart regenerationheart repairimprovedinsightischemia injuryischemic injurymRNA Differential Displaysmodel organismmouse modelmultiomicsmultiple omicsmurine modelmuscle fiber repairmuscle repairmuscle tissue repairmuscular repairmutantmyocardial ischemia/hypoxiamyocardium ischemianeonatal miceneutrophil proteinase 3novelontogenyoverexpressoverexpressionp29p29bpanomicspathwaypediatricpheochromacytoma cell-3regenerateregeneration abilityregeneration capacityregeneration potentialregeneration responseregenerativeregenerative potentialresponsesocial roletranscriptome sequencingtranscriptomic sequencingvalidations
Description preview
Project Summary
Ischemic heart disease is the leading cause of death worldwide, in part because human heart muscle fails to
regenerate after ischemic injury. A primary barrier to human heart regeneration is the near-complete absence
of cardiomyocyte cell division following a myocardial infarction (MI). Fortuitously, injured hearts of adult…
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