grant
Investigating the immunomodulatory role of the Nonclassical MHC Molecule HLA-F in Human Pregnancy
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 2 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY20261st trimester3-D3-Dimensional3DAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAdenoviridaeAdenovirusesAdoptedAlternate SplicingAlternative RNA SplicingAlternative SplicingAmino AcidsAntibodiesAntigensApplications GrantsAtlasesAutoimmune Diseases of the Nervous SystemAutoimmune StatusAutoimmune neurologic conditionAutoimmunityAutoregulationBindingBody TissuesCD94CancersCell BodyCell LineCell surfaceCellLineCellsChaperoneCloningCo-cultureCocultivationCocultureCoculture TechniquesCuesCytotoxic cellDataEarly Placental PhaseEffector CellEndocrine Gland SecretionFamilyFamily memberFirst Pregnancy TrimesterFirst TrimesterFundingGenetic PolymorphismGestationGoalsGrant ProposalsHIVHistocompatibility ComplexHistocompatibility ComplicesHomeostasisHormonesHost DefenseHumanHuman Immunodeficiency VirusesImmuneImmunesImmunityImmunomodulationInfectionInflammatoryInvadedIsoformsK lymphocyteKLRD1KLRD1 geneKP43Killer Cell Lectin-Like Receptor Subfamily D, Member 1 GeneLAV-HTLV-IIILate pregnancyLengthLigandsLinkLymphadenopathy-Associated VirusMajor Histocompatibility ComplexMajor Histocompatibility ComplicesMalignant CellMalignant NeoplasmsMalignant TumorMethodsModelingModern ManMolecularMolecular ChaperonesMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryNK CellsNK T cellNKT cellNatural Killer CellsNatural Killer T cellNervous System Autoimmune DisordersNeurologic Autoimmune DiseasesPeptidesPhysiological HomeostasisPlayPopulationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPregnancyProductionProtein IsoformsProtein ModificationProteinsPublishingRNA SplicingReagentReceptor CellReceptor ProteinRecombinantsReproductionReproduction ImmunologyReproductive ImmunologyRoleSourceSpecificitySplicingStrains Cell LinesT-CellsT-LymphocyteTestingTissuesTranscriptVariantVariationViralVirus-HIVWorkaminoacidautoimmune disease in the nervous systemautoimmune-driven neurological diseasecancer cellcell typeconformationconformationalconformational stateconformationallyconformationsconformercultured cell linecytokineearly in pregnancyearly pregnanciesearly pregnancyearly stage of pregnancyextracellularfetalhealthy pregnancyhigh definitionhigh-resolutionimmune modulationimmune regulationimmunogenimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryinsightmalignancymembernatural killer T lymphocyteneoplasm/cancerneuro-autoimmune disorderneurologic autoimmune disorderpathogenpolymorphismprotein complexreceptorscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolethree dimensionalthymus derived lymphocytetrafficking
Description preview
Project Summary/Abstract
HLA-F is a nonclassical class I MHC (Ib) molecule that has been found expressed on a variety of cancers,
shown to play a role in HIV and adenoviral infection, the neurological autoimmune disease ALS and, relevant
to this application, is expressed throughout pregnancy. Despite the potential importance of this protein in…
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