grant
Investigating the EBV methylome in PLWH: Discovery and Development of Novel EBV Diagnostics in Plasma and Saliva
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 8 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AIDS VirusAIDS lymphomaAIDS-Associated LymphomaAIDS-Related LymphomaAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAgeAssayAutopsyBS-seqBaltimoreBioassayBiological AssayBisulfite-based sequencingBlood PlasmaBlood Plasma CellBurkitt HerpesvirusBurkitt LymphomaBurkitt Lymphoma VirusBurkitt TumorBurkitt's Lymphoma/LeukemiaBurkitt's Type Small Non-Cleaved Cell LymphomaCD4 Lymphocyte CountCD4+ Cell CountsCD4+ CountsCancersCause of DeathChicagoDLBCLDNADNA MarkersDNA MethylationDNA analysisDNA biomarkersDataDeoxyribonucleic AcidDevelopmentDiagnosisDiagnosticDiffuse Immunoblastic LymphosarcomaDiffuse Large B-Cell LymphomaEB virusEBVEBV associated lymphomaEBV induced lymphomaEBV latencyEBV lymphomaEBV malignanciesEBV(+) lymphomaEBV(+) malignancyEBV+ lymphomaEBV+ve lymphomaEBV-Related MalignancyEBV-associated cancersEBV-associated malignancyEBV-positive cancerEBV-positive lymphomasEBV-positive malignancyEBV-positive malignant tumorEBV-related cancerEBV-related lymphomaEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpstein Barr VirusEpstein Barr Virus Associated LymphomaEpstein Barr Virus LymphomaEpstein Barr Virus MalignancyEpstein Barr Virus associated cancersEpstein Barr Virus driven lymphomaEpstein Barr Virus positive cancerEpstein Barr induced lymphomaEpstein-Barr Virus associated malignancyEpstein-Barr Virus latencyEpstein-Barr Virus-Related LymphomaEpstein-Barr Virus-Related MalignancyEpstein-Barr Virus-Related Malignant NeoplasmEvaluationExpression SignatureFutureGene Action RegulationGene ExpressionGene Expression ProfileGene Expression RegulationGene RegulationGene Regulation ProcessGenesGerminoblastic SarcomaGerminoblastomaHHV-4HHV4HIVHIV Associated LymphomaHIV LymphomaHIV-Related LymphomaHodgkin DiseaseHodgkin DisorderHodgkin lymphomaHodgkin'sHodgkin's LymphomaHodgkin's diseaseHodgkins lymphomaHuman Herpesvirus 4Human Immunodeficiency VirusesImmunoblastic LymphomaImmunoblastic SarcomaImmunoblastomaInfectious Mononucleosis VirusInvestigationLAV-HTLV-IIILMICLarge-Cell Immunoblastic LymphomaLymphadenopathy-Associated VirusLymphomaMalignant LymphogranulomaMalignant LymphomaMalignant Nasopharyngeal NeoplasmMalignant Nasopharyngeal TumorMalignant NeoplasmsMalignant TumorMalignant Tumor of the NasopharynxMalignant neoplasm of nasopharynxMethylationModelingModificationNasopharyngeal CancerNasopharynx CancerOrganPathway interactionsPatientsPatternPersonsPlasmaPlasma CellsPlasma SerumPlasmablastic LymphomaPlasmacytesPopulationPrevalenceRNA SeqRNA sequencingRNAseqReticuloendothelial System, Serum, PlasmaReticulolymphosarcomaSalivaSamplingScreening for cancerSourceSpecificitySystemT4 Lymphocyte CountTestingTrainingValidationViralViral GenesViral GenomeViral LatencyVirus LatencyVirus-HIVaccess to health careaccessibility of health careaccessibility to health careagesanalyze DNAbisulfite sequencingbisulfite-seqcell free DNAcell free circulating DNAcohortcostdesigndesigningdevelopmentalearly cancer detectionepigeneticallyepigenomegene expression patterngene expression signatureglobal gene expressionglobal transcription profilehealth care accesshealth care availabilityhealth care service accesshealth care service availabilityimprovedlarge cell Diffuse non-Hodgkin's lymphomalatent infectionliquid biopsylow and middle-income countrieslymphoblastoid cell linemalignancymethylation patternmethylomenecropsyneoplasm/cancernovelpathwayplasmocytepoint of carepostmortemprimary effusion lymphomarapid assayrapid testrapid testssample collectionscreeningscreening cancer patientsscreeningssexspecimen collectiontranscriptional profiletranscriptional signaturetranscriptometranscriptome sequencingtranscriptomic sequencingtumorvalidationsvirus genome
Description preview
ABSTRACT
EBV(+) lymphomas are an important cause of death in people living with HIV (PLWH). Different patterns of viral
and cellular gene expression have been found to characterize different subtypes of EBV(+) lymphomas. CpG
methylation of EBV DNA is an important epigenetic regulator of viral and cellular gene expression. At present,
we have a…
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