grant
Investigating the contribution of a novel monocyte transcriptional state to sepsis immunopathogenesis and patient heterogeneity
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 16 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025Accident and Emergency departmentAtlasesAutomobile DrivingBlood SampleBlood monocyteBlood specimenCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCell BodyCell Communication and SignalingCell Cycle KineticsCell KineticsCell SignalingCell surfaceCellsClassificationClinicalCohort StudiesCommunicable DiseasesConcurrent StudiesConvalescenceDataDetectionDevelopmentDevelopment PlansDysfunctionElementsEmergency DepartmentEmergency roomExpression SignatureFunctional disorderGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfileGene Expression ProfilingGene TranscriptionGeneral HospitalsGenesGenetic TranscriptionGenomicsGoalsHeterogeneityHumanImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune responseImmunesImmunochemical ImmunologicImmunologicImmunologic DiseasesImmunologicalImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologicallyImmunologicsImmunologyImmunology procedureImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIndividualInfectionInfectious DiseasesInfectious DisorderIntracellular Communication and SignalingInvestigationKineticsLifeMarrow monocyteMassachusettsMeasuresMedicineMemoryMentorshipModern ManMorbidityMorbidity - disease rateMyeloid-derived suppressor cellsNoiseOrganOrgan failureOutcomePBMCPatientsPeripheral Blood Mononuclear CellPhagocytosisPhenotypePhysiciansPhysiopathologyPopulationPrecision therapeuticsProliferatingProteomePublicationsRNA ExpressionRNA SeqRNA sequencingRNAseqResearchResolutionRoleScientific PublicationScientistSepsisSeveritiesSignal TransductionSignal Transduction SystemsSignalingSingle cell seqSourceStimulusSubgroupSystemSystematicsT-Cell ActivationT8 CellsT8 LymphocytesTestingTimeTrainingTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranslational Research EnterpriseUncertaintyUrinary tract infectionUrinary tract infectious diseaseVariantVariationactivate T cellsanalyze gene expressionbacterial sepsisbiological signal transductionbiomarker signaturecareercareer developmentclinical applicabilityclinical applicationclinical heterogeneitycohortcytotoxicdetermine efficacydevelopmentaldoubtdrivingefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacygene expression analysisgene expression assaygene expression patterngene expression signaturegene signaturesgenetic signatureglobal gene expressionglobal transcription profilehost responseimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunologic assayimmunologic assay/testimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressedimmunosuppressive activityimmunosuppressive functionimmunosuppressive myeloid cellsimmunosuppressive responseimprovedindividuals with sepsisinsightinstructormedical collegemedical schoolsmicrobialmonocytemortalitymyeloid suppressor cellsmyeloid-derived suppressive cellsnovelpathogenpathophysiologypatient stratificationpatients with sepsispeople with sepsispersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentprecision therapiesprecision treatmentprognosticresolutionsresponsescRNA sequencingscRNA-seqschool of medicinesepsis groupssepsis patientssepsis populationsepsis subjectsseptic groupseptic individualsseptic patientsseptic peopleseptic populationseptic subjectsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell next generation sequencingsingle cell sequencingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssocial rolestratified patientsubjects with sepsissuppressive myeloid cellstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttooltranscriptional profiletranscriptional profilingtranscriptional signaturetranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstranslation research enterprisetranslational research programtreatment strategyurinary infectionurinary sepsisurosepsis
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Project Summary/Abstract
Sepsis is characterized by life-threatening organ failure caused by dysfunctional immune
responses to infection; however, the specifics of immune dysfunction are poorly understood and
vary widely among patients. Single-cell RNA sequencing (scRNA-seq) enables gene-level
analysis of individual immune cell responses during…
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