grant
Investigating the combined role of APOE4 and ketogenic diets in Alzheimer's disease
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 15 Aug 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY20263 Hydroxybutyrate65 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAD and related dementiaAD dementiaAD pathwayAD related dementiaAD riskAD risk factorAD-associated pathwaysAD-related pathwaysAD-specific pathwaysADRDAPOEAPOE e3APOE e4APOE-ε4APOEε4AccelerationAcetyl CoAAcetyl Coenzyme AAffectAgeAged 65 and OverAgreementAllelism TestAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease mechanismAlzheimer pathwayAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's Disease PathwayAlzheimer's Disease and its related dementiasAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimer's mechanismAlzheimer's related pathwaysAlzheimers DementiaAmentiaApo-EApoE proteinApolipoprotein EAssayAstrocytesAstrocytusAstrogliaAutoregulationAxonBioassayBioavailabilityBiochemicalBiologicalBiological AssayBiological AvailabilityBiological MarkersBloodBlood - brain barrier anatomyBlood Reticuloendothelial SystemBlood-Brain BarrierBody TissuesBrainBrain DiseasesBrain DisordersBrain Nervous SystemCarbohydratesCausalityCell BodyCellsCerebrovascular systemChemicalsCholesterolCholesterol HomeostasisClinical ResearchClinical StudyClinical TrialsClinical stratificationCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplementComplement ProteinsComplementation TestComplexCoupledD-GlucoseDataDegenerative Neurologic DisordersDementiaDepositDepositionDevelopmentDextroseDiagnosticDietDiet and NutritionDietary InterventionDisturbance in cognitionEncephalonEncephalon DiseasesEnvironmentEtiologyFDA licensed drugsFDA-approved agentsFDA-approved drugFDA-approved medicationsFDA-approved pharmaceuticalsFDA-approved therapeutic agentFatsFatty acid glycerol estersFinancial costFood and Drug Administration approved drugFood and Drug Administration approved medicationsFood and Drug Administration approved pharmaceuticalsFoundationsGI microbiomeGene ModifiedGene TranscriptionGene variantGenesGeneticGenetic Complementation TestGenetic TranscriptionGenetic predisposing factorGenotypeGliaGlial CellsGlucoseHemato-Encephalic BarrierHomeostasisHumanImmuneImmunesImpaired cognitionImpairmentIn VitroIndividualInflammationInterventionIntracranial CNS DisordersIntracranial Central Nervous System DisordersIsocaloricKetonesKetosisKnowledgeKolliker's reticulumLipidsMetabolicMethodsMiceMice MammalsModern ManMolecularMurineMusNational Institutes of HealthNatureNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeuroimmuneNeurologic Degenerative ConditionsNeuron DegenerationNon-neuronal cellNonneuronal cellNutrition InterventionsNutritional InterventionsOlder PopulationOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOutcomePathogenesisPathogenicityPathologicPathway interactionsPeripheralPersonsPhysiologic AvailabilityPhysiological HomeostasisPrimary Senile Degenerative DementiaProcessProductionPublishingRNA ExpressionRegimenResistanceRisk-associated variantRoleS-acetate Coenzyme ASignal PathwaySystemTREM2TREM2 geneTechnologyTestingTherapeuticTherapeutic InterventionTissuesTrans TestTranscriptionTriggering Receptor Expressed in Myeloid Cells 2Triggering Receptor Expressed on Myeloid Cells 2United States National Institutes of HealthUpregulationVariantVariationabove age 65after age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardaged 65 and greateraged 65+aged ≥65agesallelic variantalzheimer riskapo E-3apo E-4apo E3apo E4apo epsilon4apoE epsilon 4apoE-3apoE-4apoE3apoE4apolipoprotein E epsilon 4apolipoprotein E-3apolipoprotein E-4apolipoprotein E3apolipoprotein E4astrocytic gliabeta-Hydroxybutyratebio-markersbiologicbiologic markerbiomarkerblood vessels in the brainbloodbrain barrierbrain blood vesselsbrain tissuebrain vasculaturecausationcell typecerebral blood vesselcerebral vasculaturecerebrovascular vesselscerebrovasculaturecholesterol biosynthesischolesterol metabolismcholesterol traffickingcognitive abilitycognitive dysfunctioncognitive losscomplementationcomplementation analysiscomplementation approachdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldiagnostic approachdiagnostic biomarkerdiagnostic markerdiagnostic strategydiet interventiondietarydietsdigestive tract microbiomedisease causationenteric microbiomegastrointestinal microbiomegene modificationgenetic approachgenetic risk factorgenetic strategygenetic variantgenetically modifiedgenomic variantgut microbiomegut-associated microbiomehuman modelhuman old age (65+)humanized micehumanized mouseiPSiPSCiPSCsimprovedin vitro Modelin vivoinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinherited factorinnovateinnovationinnovativeinsightintervention therapyintestinal biomeintestinal microbiomeketo dietketogenicketogenic dietketogenticmechanisms in ADmechanisms in Alzheimer's diseasemodel of humanmonetary costmyelinationnerve cementneural degenerationneural inflammationneurodegenerationneurodegenerativeneurodegenerative illnessneuroinflammationneuroinflammatoryneurological degenerationneuronal degenerationnew diagnosticsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation diagnosticsnext generation therapeuticsnovel diagnosticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approacholder groupsolder individualsolder personover 65 yearspathwaypathways associated with ADpathways associated with Alzheimer'spathways contribute to Alzheimer'spathways involved in Alzheimer diseasepathways that contribute to ADpathways that drive ADpathways underlying Alzheimer'spre-clinical studypreclinical studyprimary degenerative dementiaresistantresponserisk allelerisk factor for developing Alzheimer'srisk factor in Alzheimer'srisk generisk genotyperisk locirisk locusrisk of developing Alzheimer'srisk variantscRNA sequencingscRNA-seqsenile dementia of the Alzheimer typesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettherapeutically effectivetranscriptomicsβ-Hydroxybutyrate≥65 years
Description preview
Abstract Diet and nutrition influence our cognitive abilities, how our brains age, and vulnerability to
neurodegeneration. However, the interaction of diet with the human brain is complex and influenced by every
person’s unique genetic composition. Clinical studies found that ketogenic diets and supplements improve
cognition and protect against…
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