grant
Investigating the cellular and molecular mechanisms of periventricular inflammation in neuroinflammatory CNS
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2026AD dementiaAblationAbscissionAbsence of interventricular septumAdoptedAffectAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnimal ModelAnimal Models and Related StudiesAreaArteriosclerotic DementiaAstrocytesAstrocytusAstrogliaAttenuatedAutomobile DrivingBehavioral SymptomsBioinformaticsBlood - brain barrier anatomyBlood-Brain BarrierBrainBrain InflammationBrain Nervous SystemBrain VentricleBrain imagingCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsCerebral VentriclesCerebrospinal FluidChoroid PlexusChronicClinicalCognitive DisturbanceCognitive ImpairmentCognitive ManifestationsCognitive SymptomsCognitive declineCognitive function abnormalCommon VentricleComplementComplement 3Complement Component 3Complement ProteinsCor triloculare biatriatumDataDegenerative Neurologic DisordersDemyelinating DiseasesDemyelinating DisordersDemyelinationsDiseaseDisease OutcomeDisease ProgressionDisorderDisseminated SclerosisDisturbance in cognitionEAEEncephalitisEncephalonEpendymal CellEpendymocyteEventExcisionExperimental Allergic EncephalitisExperimental Allergic EncephalomyelitisExperimental Autoimmune EncephalitisExperimental Autoimmune EncephalomyelitisExpression SignatureExtirpationFoundationsFutureGene Expression ProfileGliaGlial CellsGliosisGoalsHandHemato-Encephalic BarrierHortega cellHumanImageImmuneImmune infiltratesImmunesImmunofluorescence MicroscopyImpaired cognitionIndividualInflammationInflammation MediatorsInflammatoryInnate Immune SystemIntracellular Communication and SignalingKolliker's reticulumLearningLigandsMR ImagingMR TomographyMRIMRI ScansMRIsMagnetic Resonance ImagingMagnetic Resonance Imaging ScanMediatingMediatorMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMiceMice MammalsMicrogliaModelingModern ManMolecularMolecular GeneticsMonitorMultiple SclerosisMurineMusNMR ImagingNMR TomographyNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeurologic DisordersNeurological DisordersNon-neuronal cellNonneuronal cellNuclear Magnetic Resonance ImagingOutcomePathologyPeripheralPhasePhenotypePhysiciansPlayPrimary Senile Degenerative DementiaProcessProteinsProteomicsReceptor ProteinRemovalRoleScientistSeveritiesSignal TransductionSignal Transduction SystemsSignalingSourceStrains Cell LinesStructure of choroid plexusSurgical RemovalSynapsesSynapticTestingTherapeuticTimeTrainingUpregulationValidationVascular DementiaVentricularVirusWhite Matter HyperintensityWorkZeugmatographyage associated dementiaage induced dementiaage related dementiaaging associated dementiaaging related dementiaastrocytic gliaattenuateattenuatesautoimmune encephalomyelitisbiological signal transductionbloodbrain barrierbrain parenchymabrain visualizationcareercerebral spinal fluidcerebrovascular contributions to dementiacognitive dysfunctioncognitive losscomplementationcultured cell linecytokinede-myelinating diseasesde-myelinating disordersdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdemyelinatedemyelinating conditionsdemyelination diseasesdemyelination disordersdrivinggene expression patterngene expression signaturegitter cellhandshuman diseaseimagingimmune cell infiltratein vivoinflammatory mediatorinsightinsular sclerosismesogliamicroglial cellmicrogliocytemodel of animalmouse modelmurine modelnerve cementneural imagingneural inflammationneuro-imagingneurodegenerative illnessneuroimagingneuroinflammationneuroinflammatoryneurological diseaseneurological imagingnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathogenperivascular glial cellprimary degenerative dementiareceptorresectionscRNA sequencingscRNA-seqsenile dementia of the Alzheimer typesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle functional ventriclesingle ventriclesingle-cell RNA sequencingsocial rolespinal fluidsubstantia albasynapsetherapeutic targettooltranscriptional profiletranscriptional signaturetranscriptomicsuniventricular heartvalidationsvascular contributions in dementiavascular contributions to dementiavascular related dementiawhite matterwhite matter damage
Description preview
PROJECT ABSTRACT
The goal of the proposal is to understand the cellular and molecular mechanisms driving
periventricular inflammation in demyelinating disease and define the role of ependymal cell (EPC)
derived complement component 3 (C3) in mediating this process. Periventricular inflammation has been
identified as an early event in many…
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