grant
Investigating stochastic genome folding as a mechanism to generate cell-surface protein diversity required for neural self-avoidance
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Mar 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAblationAddressAllelesAllelomorphsArchitectureAssayBase PairingBioassayBiologic ModelsBiological AssayBiological ModelsBrainBrain Nervous SystemCell BodyCell Culture SystemCell Surface ProteinsCellsChromatinChromatin LoopChromatin Loop DomainsChromosomesComplexCoupledCouplingDNA LoopDNA MethylationDataDecision MakingDevelopmentDiseaseDisorderEncephalonEngineering / ArchitectureEnhancersGene Action RegulationGene ArrangementGene ClusterGene ExpressionGene Expression RegulationGene InactivationGene OrderGene PositionGene RegulationGene Regulation ProcessGene SilencingGene TranscriptionGenerationsGenesGeneticGenetic TranscriptionGenomeGenomic DNAGenomic approachGoalsHealthHeterochromatinHumanIndividualInstructionIsoformsLabelLifeLinkMaintenanceMammaliaMammalsMapsMeasuresMemoryMiceMice MammalsModel SystemModelingModern ManMolecularMurineMusNamesNatureNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeural DevelopmentNeuritesNeurocyteNeurologic DisordersNeurological DisordersNeuronsNon-Polyadenylated RNANuclearOpticsPatternPhysiologicPhysiologicalPlayProcessProgenitor CellsPropertyProtein IsoformsProteinsProteomePublishingRNARNA ExpressionRNA Gene ProductsReaderRegulationResearch ProposalsResolutionRestRibonucleic AcidRoleShapesStructureTestingTranscriptTranscriptioncell typecohesincombinatorialdevelopmentalgDNAgenomic effortgenomic strategyhistone methylationin vivomouse modelmurine modelnamenamednamingneuralneural circuitneural circuitryneural controlneural patterningneural regulationneurocircuitryneurodevelopmentneurological diseaseneuromodulationneuromodulatoryneuronalneuropsychiatric diseaseneuropsychiatric disorderneuroregulationolfactory sensory neuronsopticalpostmitoticpreventpreventingpromoterpromotorprotein complexreconstructionresolutionssingle cell genomicssocial rolestem cellssynaptic circuitsynaptic circuitrythree dimensionaltranscriptional silencing
Description preview
PROJECT SUMMARY
During brain development, the assembly of functional neural circuits necessitates sophisticated regulation of
neural arborization patterns. This mechanism is achieved by a process known as neural self-avoidance, which
allows projections from the same neuron to recognize and avoid self. In mammals, the regulation of neural self-…
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