grant
Investigating retrotransposon activity-mediated EMT plasticity and immune cell dysfunction in pancreatic ductal adenocarcinoma
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAnti-OncogenesAntigensAntioncogenesArchitectureAssayBar CodesBioassayBiological AssayBiological FunctionBiological ProcessC-K-RASCUT&RUNCancer Suppressor GenesCell BodyCell Mediated ImmunologyCell-Mediated ImmunityCell-Mediated Lympholytic CellsCellsCellular ImmunityCharacteristicsChromatinChromatin LoopChromatin Loop DomainsChromosome MappingCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseComplexCytolytic T-CellCytotoxic T CellCytotoxic T-LymphocytesDNA LoopDataDedicationsDependenceDevelopmentDiagnosisDisease ProgressionDysfunctionEmerogenesEngineering / ArchitectureEvolutionExpression SignatureFunctional disorderGEM modelGEMM modelGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfileGene Expression ProfilingGene LocalizationGene MappingGene Mapping GeneticsGenesGeneticGenetically Engineered MouseGoalsHigh Throughput AssayImmuneImmune EvasionImmune responseImmunesImmunologic SubtypingImmunophenotypingIntratumoral heterogeneityK-RAS2AK-RAS2BK-RasK-Ras 2AK-Ras-2 OncogeneKRASKRAS driven oncogenesisKRAS oncogenesisKRAS-driven tumorigenesisKRAS-mediated tumorigenesisKRAS2KRAS2 geneKi-RASLaboratoriesLinkage MappingLungLung NeoplasmsLung Respiratory SystemLung TumorMaintenanceMalignant CellMalignant Pancreatic NeoplasmMalignant Tumor of the LungMalignant neoplasm of lungMalignant neoplasm of pancreasMediatingMediatorMentorsMethodologyMiceMice MammalsMolecularMolecular ConfigurationMolecular ConformationMolecular StereochemistryMolecular Tumor SuppressionMurineMusOnco-Suppressor GenesOncogene K-RasOncogenes-Tumor SuppressorsOncogenesisPDA modelPDAC ModelPancreas CancerPancreas Ductal AdenocarcinomaPancreatic CancerPancreatic Ductal AdenocarcinomaPhasePhysiopathologyPlayPositionPositioning AttributePostdocPostdoctoral FellowProteinsPulmonary CancerPulmonary NeoplasmsPulmonary malignant NeoplasmR-Series Research ProjectsR01 MechanismR01 ProgramRASK2Recessive OncogenesRegulationResearchResearch AssociateResearch GrantsResearch Project GrantsResearch ProjectsRetrotransposonRoleShapesSpecialtySystemT cell responseT-CellsT-LymphocyteT-StageTechniquesTimeTotal Human and Non-Human Gene MappingTrainingTranscript Expression AnalysesTranscript Expression AnalysisTumor CellTumor ImmunityTumor SubtypeTumor Suppressing GenesTumor SuppressionTumor Suppressor GenesTumor Suppressor ProteinsTumor VolumeTumor stageWorkanalyze gene expressionanti-tumor immune responseanti-tumor immunityantitumor immunitybarcodecancer cellcancer immunitycancer immunologycancer progressioncancer typecandidate identificationcell typechemotherapycohesinconformationconformationalconformational stateconformationallyconformationsdevelopmentalexperienceexperimentexperimental researchexperimental studyexperimentsfunctional genomicsgene expression analysisgene expression assaygene expression patterngene expression signaturegene functiongenetic mappinggenetically engineered mouse modelgenetically engineered murine modelheterogeneity in tumorshigh throughput screeninghost responseimmune evasiveimmune system responseimmunogenimmunoresponsein vivoinnovateinnovationinnovativeinsightintra-tumoral heterogeneityintratumor heterogeneitykiller T celllung cancerlung cancer celllung tumorigenesismedical specialtiesmouse modelmultidisciplinarymultiomicsmultiple omicsmurine modelneoplasm immunologyneoplasm progressionneoplastic cellneoplastic progressionnew approachesnovelnovel approachesnovel strategiesnovel strategyoncogenic KRASoncosuppressor genepancreatic ductal adenocarcinoma modelpancreatic malignancypanomicspathophysiologypost-docpost-doctoralpost-doctoral traineeresearch associatesresponsesocial rolethree dimensionalthymus derived lymphocytetranscriptional profiletranscriptional profilingtranscriptional signaturetumortumor growthtumor heterogeneitytumor immunologytumor progressiontumor suppressortumorigenesistumorigenesis in the lungv-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog
Description preview
PROJECT SUMMARY
Lung and pancreatic ductal adenocarcinomas are often diagnosed at very late stages of tumor progression when
they are most aggressive and difficult to treat. Currently, very little is known about the characteristics that make
up the complex tumor heterogeneity of late-stage tumors and what factors contribute to such changes in…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click