grant
Investigating non-canonical mechanisms of endogenous opioids on motivation in dorsal midbrain
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 9 Mar 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY202621+ years oldActive Follow-upAdultAdult HumanAffectAffectiveAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnatomic SitesAnatomic structuresAnatomyAnodynesAntinociceptive AgentsAntinociceptive DrugsAppetiteAppetite stimulatedBehaviorBehavioralBiologicalBiteBrainBrain Nervous SystemCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCalciumCas nuclease technologyCell Communication and SignalingCell NucleusCell SignalingCharacteristicsChronicClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCodeCoding SystemColorDataDesire for foodDevicesDissociationDorsalE-stimEatingElectric StimulationEncephalonEndoscopyEnkephalin ReceptorsEnkephalinsFISH TechnicFISH TechniqueFISH analysisFISH assayFluorescence In Situ HybridizationFluorescent in Situ HybridizationFood IntakeGeneticGoalsHealth Care CostsHealth CostsImageIncreased food appetiteIndividualInfumorphIntracellular Communication and SignalingKadianLateralLigandsMS ContinMSirMeasuresMediatingMental disordersMental health disordersMesencephalic Central GrayMesencephalonMiceMice MammalsMicroinjectionsMid-brainMidbrainMidbrain Central GrayMidbrain structureMoodsMorphiaMorphineMotivationMurineMusNIMHNational Institute of Mental HealthNerve CellsNerve UnitNeural CellNeurocyteNeuronsNucleusNucleus AccumbensOpiate PeptidesOpiate ReceptorsOpiate agonistOpiate receptor agonistOpiatesOpioidOpioid PeptideOpioid ReceptorOpioid agonistOpioid receptor agonistOpsinOramorphOramorph SRPatternPeptidesPeriaqueductal GrayPharmacologyPhenotypePhotonsPilot ProjectsPlayProcessPsychiatric DiseasePsychiatric DisorderReceptor ProteinRegulationRewardsRod-OpsinRoleRoxanolSignal TransductionSignal Transduction SystemsSignalingSiteStatex SRStrategic PlanningSystemTailTechnologyTestingTherapeutic InterventionUnited StatesVirusactive followupadulthoodannulus of the aqueductantagonismantagonistbehavior testbehavioral testbiologicbiological adaptation to stressbiological signal transductioncalcium indicatorcell typedelta opioid receptordesigndesigningdorsal raphe nucleuselectrostimulationendogenous opiateendogenous opioidsendoscopic imagingexperienceexperimentexperimental researchexperimental studyexperimentsfluorophorefollow upfollow-upfollowed upfollowupimagingimaging in vivoin vivo imagingincreased appetiteincreased hungerinsightintervention therapyknock-downknockdownmental illnessmidbrain central gray substancemotivated behaviormu receptorsneuralneural circuitneural circuitryneural controlneural regulationneurobiological mechanismneurochemicalneurochemistryneurocircuitryneuromodulationneuromodulatoryneuronalneuropsychiatricneuropsychiatric diseaseneuropsychiatric disorderneuropsychiatryneuroregulationnext generationoptogeneticspain killerpain medicationpain relieverpainkillerperiaqueductal gray matterpharmacologicpilot studypsychiatric illnesspsychological disorderreaction; crisisreceptorreceptor expressionredshiftresponsesocial rolestress responsestress; reactionsynaptic circuitsynaptic circuitrytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentwirelesswireless implantδ ORδ ORsδ opioid receptorsδ-ORδ-ORsδORδORsμ receptors
Description preview
Project Summary
The primary goal of this R01 is to determine the computational and functional role of endogenous opioids in
specific dorsal midbrain nuclei on motivated behaviors. The preponderance of mental illness in the United States
results in tens of millions of dollars in healthcare costs. While many neuropsychiatric conditions can be…
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