grant

Investigating Neuroprotective Roles of BCAT1 During Hypoxia

Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 24 Sept 2025Deadline 24 Jul 2028
NIHUS FederalResearch GrantFY20252-ketoglutarate2-oxoglutarateASDAcquired brain injuryActive OxygenAffectAmino AcidsAspartate AminotransferasesAspartate ApoaminotransferaseAspartate TransaminaseAssayAutismAutistic DisorderBaby FormulaBioassayBioinformaticsBiological AssayBrainBrain Hypoxic InjuryBrain InjuriesBrain Nervous SystemBrain TraumaBranched-Chain Amino AcidsCNS Nervous SystemCatabolismCell AnoxiaCell HypoxiaCell SurvivalCell ViabilityCellular AnoxiaCellular HypoxiaCentral Nervous SystemChromatinDataDevelopmentDiagnosisEarly Infantile AutismElectron TransportEmbryoEmbryonicEncephalonEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpilepsyEpileptic SeizuresEpilepticsEssential Amino AcidsEventExposure toFetusGene ExpressionGlutamate-Aspartate TransaminaseGlutamatesGlutamic-Oxaloacetic TransaminaseGoalsHypoxiaHypoxicHypoxic Brain DamageInduced pluripotent stem cell derived human neuronInfantInfant formulaInfantile AutismInjuryIntermediary MetabolismInterventionIsoleucineKanner's SyndromeKeto AcidsL-Aspartate-2-Oxoglutarate AminotransferaseL-GlutamateL-ValineLC/MSLabelLaboratoriesLeucineMeasurementMeasuresMediatingMetabolicMetabolic ProcessesMetabolismMiceMice MammalsMitochondriaMolecularMorphologyMurineMusNeonatal asphyxia-induced brain injuryNeonatal hypoxic brain injuryNerve CellsNerve UnitNeural CellNeuraxisNeurocyteNeurodevelopmental DisabilityNeurodevelopmental DisorderNeurologic DysfunctionsNeurologic outcomeNeurological Development DisorderNeurological outcomeNeuronal HypoxiaNeuronal InjuryNeuronsO elementO2 elementOxidative StressOxygenOxygen DeficiencyOxygen RadicalsPathologic ProcessesPathological ProcessesPerinatal Brain InjuryPerinatal HypoxiaPerinatal brain damagePhenotypePlayPro-OxidantsProductionProtein TraffickingRNA SeqRNA sequencingRNAseqReactive Oxygen SpeciesRegulationResearchRoleSeizure DisorderStressSupplementationTechniquesTestingTherapeuticTherapeutic InterventionTimeTrainingTraumatic Brain InjuryUpregulationValineWorkalpha ketoglutarateamino acid metabolismamino groupaminoacidautism spectral disorderautism spectrum disorderautistic spectrum disorderbrain damagebrain-injuredbranched amino acidsbranched chain amino acid aminotransferasebranched-chain L-amino-acid aminotransferasebranched-chain aminotransferasesbranched-chain-amino-acid transaminasecell typecofactordevelopmentalelectron transferepigeneticallyepilepsiaepileptogenicfetalglutamate-branched chain amino acid transaminaseglutamatergicglutamic aspartic transaminasehiPSChiPSC-derived neuronshistone methylationhuman iPShuman iPSChuman iPSC-derived sensory neuronhuman induced pluripotent cellhuman induced pluripotent stem cell derived sensory neuronhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshypoxic ischemic encephalopathyiPSC-derived human neuronimprovedin vitro Assayinduced human pluripotent stem cellsinducible pluripotent stem cell derived human neuroninducible pluripotent stem cell derived human sensory neuroninjuriesinnovateinnovationinnovativeinsightinterestintervention therapyketoacidknock-downknockdownliquid chromatography mass spectrometrymRNA sequencingmRNA-seqmRNAseqmetabolism measurementmetabolomicsmetabonomicsmilk formulamitochondrialneonatal HIEneonatal brain hypoxia-ischemianeonatal hypoxia-ischemianeonatal hypoxic-ischemic brain damageneonatal hypoxic-ischemic brain injuryneonatal hypoxic-ischemic encephalopathyneurodevelopmental diseaseneurological dysfunctionneuron injuryneuronalneurons differentiated from human induced pluripotent stem cellsneuroprotectionneuroprotectivenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoverexpressoverexpressionprenatalprotein transportresponseskillssocial rolestable isotopetraining opportunitytransaminase Atransaminase Btranscriptome sequencingtranscriptomic sequencingtraumatic brain damageunbornα-ketoglutarateα-oxoglutarateαKG
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PROJECT SUMMARY:
Hypoxic ischemic encephalopathy (HIE) is a developmental brain injury caused by transient reductions in oxygen
supply to the term fetus. HIE is a significant cause of neurodevelopmental disorders like autism and epilepsy,
suggesting that prenatal hypoxia exposure can cause lifelong neurological dysfunction. The underlying…

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Investigating Neuroprotective Roles of BCAT1 During Hypoxia — UNIVERSITY OF PENNSYLVANIA | UNITED STATES | Sept 2025 | Dev Procure