grant

Investigating neuronal hyperactivity as a link between amyloid-beta and tau spreading in Alzheimer's disease (NeurActAmy)

Organization UKRILocation United Kingdom
UKRIUK ResearchGrantActive
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In Alzheimer's disease (AD), the amyloid-beta-associated aggregation of tau triggers neurodegeneration and cognitive decline; hence, preventing tau aggregation is a key therapeutic target. Preclinical research found that i) amyloid-beta precipitates neuronal hyperactivity, ii) neuronal hyperactivity promotes synaptic release of soluble…

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Investigating neuronal hyperactivity as a link between amyloid-beta and tau spreading in Alzheimer's disease (NeurActAmy | Dev Procure