grant
Investigating Neisseria gonorrhoeae chromosomal replication dynamics
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025Antibiotic ResistanceAntigen VariationAntigenic VariabilityAntigenic VariationAntimicrobial ResistanceB subtilisB. subtilisBacillus subtilisBacteriaBacterial ChromosomesBindingBlindnessCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCell BodyCell CycleCell Division CycleCellsChromosomesClustered Regularly Interspaced Short Palindromic Repeats interferenceCompensationConserved SequenceCoupledDNADNA ContentDNA DamageDNA IndexDNA InjuryDNA PloidyDNA Replication InitiationDNA mutationDataDeoxyribonucleic AcidEnteralEntericEpisomeFilamentFimbriae ProteinsFrequenciesGene ConversionGeneralized GrowthGenerationsGeneticGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisGenomeGenomicsGoalsGonococcal InfectionGonococcusGonorrheaGrowthHumanInfectionLeftLinkLocationMaintenanceMapsMeningococcusModern ManMolecularMolecular InteractionMutagenesisMutagenesis Molecular BiologyMutationN gonorrheaN lactamicaN meningitidisN. gonorrheaN. lactamicaN. meningitidisNeisseriaNeisseria gonorrhoeaeNeisseria lactamicaNeisseria meningitidisNeonatalNucleotidesOrganismPathogenicityPharyngeal structurePharynxPhysiologyPili Structural ProteinsPilinPloidiesPolymersPolyploidPolyploidyProcessProteinsPublic HealthRectumReplication InitiationReplication OriginReportingResistanceResistance to antibioticsResistant to antibioticsRoleSexually Transmitted DiseasesSexually Transmitted DisorderSexually Transmitted InfectionStressTestingThroatTissue GrowthTransmissionUrethraVenereal DiseasesVenereal DisordersVenereal Infectionsanti-microbial resistantantibiotic drug resistanceantibiotic resistantbio-informatics toolbioinformatics toolchromosome complementchromosome replicationcommensal communitycommensal microbiomecommensal speciesexperimentexperimental researchexperimental studyexperimentsgenetic approachgenetic informationgenetic strategygenome mutationhuman pathogeninsightliving systemontogenyori Regionoverexpressoverexpressionpolymerpolymericpromoterpromotorrecruitrepressing CRISPR-dCas9 systemreproductiveresident commensalsresistance to anti-microbialresistantresistant to antimicrobialsexually acquired infectionsocial roletransmission processurethralvision lossvisual loss
Description preview
PROJECT SUMMARY
Neisseria gonorrhoeae (Gc) causes one of the most common sexually transmitted infections.
Increasing antimicrobial resistance is a major public health issue. Gc has more than one copy of
its chromosome per cell, while a closely related commensal Neisseria has a single chromosomal
copy. I have identified the putative origin or…
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