grant
Investigating mechanisms of cell volume regulation in the zebrafish notochord
NIHUS FederalResearch GrantFY20253'5'-cyclic ester of AMPAcuteAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)AdhesionsAnimalsAnionsAssayAutoregulationBSC2 proteinBSC2 transport proteinBioassayBiologicalBiological AssayBiologyBiophysical ProcessBody TissuesBrachydanio rerioBuffersCFTRCFTR ProteinCalcium ChannelCalcium Channel Antagonist ReceptorCalcium Channel Blocker ReceptorsCalcium Ion ChannelsCalcium Ion SignalingCalcium SignalingCell BodyCell CommunicationCell Communication and SignalingCell FunctionCell InteractionCell PhysiologyCell ProcessCell SignalingCell SizeCell VolumesCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessChloride ChannelsChloride Ion ChannelsCuesCyclic AMPCystic Fibrosis Transmembrane Conductance RegulatorCytoplasmDanio rerioDataDevelopmentDiseaseDisorderEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentFeedbackG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGeneralized GrowthGeneticGrowthHomeostasisHydrogelsIndividualIntervertebral DiskIntervertebral disc structureIntracellular Communication and SignalingIon ChannelIonic ChannelsKnowledgeLiquid substanceLysosomesMammaliaMammalsMechanicsMediatingMembrane ChannelsMethodsModelingNKCC1 CotransporterNKCC1 proteinNKCC1 transport proteinOrganOrganellesOrganismOsmosisOutcome StudyPathway interactionsPatternPhosphorylationPhysiologicPhysiologicalPhysiological HomeostasisPiezo 1Piezo 1 ion channelPiezo1ProcessProtein PhosphorylationRegulationRoleSLC12A2 cotransporterSignal TransductionSignal Transduction SystemsSignalingSpinal ColumnSpineSubcellular ProcessSwellingSystemTestingTissue GrowthTissuesTubeVDCCVacuoleVertebral columnVertebrate AnimalsVertebratesVoltage-Dependent Calcium ChannelsWorkZebra DanioZebra FishZebrafishadenosine 3'5' monophosphatebackbonebiologicbiological signal transductionbiophysical mechanismbumetanide-sensitive cotransporter 2cAMPcystic fibrosis transmembrane regulatordevelop therapydevelopmentaldiagnostic toolexperimentexperimental researchexperimental studyexperimentsfluidin vivointervention developmentliquidliving systemmechanicmechanicalmechanical cuemechanical forcemechanical propertiesmechanical signalnotochordnovelnucleus pulposusontogenyparticlepathwaypublic health relevanceresponsescaffoldscaffoldingsocial rolesodium-potassium-chloride cotransporter 1 proteintherapy developmenttreatment developmentvertebrata
Description preview
Abstract
Animal cells achieve and maintain a typical volume through the regulation of ion channels that control osmotic
processes. In metazoans, development of properly proportioned bodies also requires volume regulation to be
coordinated amongst cells within tissues and across organs and systems. Although ion channels regulating cell
volume have…
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