grant
Investigating individual differences in alcohol abstinence associated anxiety and depression across the BNST network.
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 15 Mar 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2026AbstinenceAcuteAddressAffectAlcohol dependenceAlcohol withdrawal syndromeAmericanAmmon HornAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAnxietyBed Nucleus of Stria TerminalisBehaviorBrainBrain Nervous SystemCentral LobeCharacteristicsChronicCollaborationsCornu AmmonisDWI (diffusion weighted imaging)DWI-MRIDataDevelopmentDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDisablingEducationEducational aspectsEmotional DepressionEncephalonFunctional MRIFunctional Magnetic Resonance ImagingFundingFutureGoalsHeterogeneityHippocampusHumanHypothalamic structureHypothalamusIndividualIndividual DifferencesInfrastructureInsulaInsula of ReilInterventionIsland of ReilKnowledgeMeasuresMental DepressionMethodsModelingModern ManNIAAANational Institute on Alcohol Abuse and AlcoholismNegative ReinforcementsNeurobiologyNeurosciencesNucleus AccumbensPathway interactionsPatternPhenotypePilot ProjectsPrefrontal CortexProcessRelapseReportingResearchResidential TreatmentRestRodentRodent ModelRodentiaRodents MammalsSamplingStria Terminalis NucleusStructure of terminal stria nuclei of preoptic regionSubgroupSymptomsTechnologyTestingTimeTranslatingTranslationsVariantVariationWithdrawalWorkabstaining from alcoholabstaining from ethanolabstinence from alcoholabstinence from ethanoladdictionaddictive disorderalcohol abstinencealcohol abuse therapyalcohol abuse treatmentalcohol addictionalcohol dependencyalcohol dependentalcohol exposedalcohol exposurealcohol related researchalcohol researchalcohol seekingalcohol seeking behavioralcohol treatmentalcohol use disorderalcohol withdrawalalleviate symptomameliorating symptomamygdaloid nuclear complexanxiety symptomsanxiety-like behavioranxious symptomclinical significanceclinically significantdMRIdecrease symptomdepressiondepression symptomdepressivedepressive symptomsdevelopmentaldiffusion tensor imagingethanol abstinenceethanol exposedethanol exposureethanol researchethanol seekingethanol use disorderethanol withdrawalethanol-seeking behaviorexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolfMRIfewer symptomshippocampalhypothalamicimage-based methodimaging methodimaging modalityinnovateinnovationinnovativelong-term recoverymodel of animalnegative affectnegative affectivityneuralneural circuitneural circuitryneural imagingneuro-imagingneurobiologicalneurocircuitryneuroimagingneurological imagingnovelpathwaypersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpilot studypreventprevent relapsepreventingreduce symptomsrelapse preventionrelieves symptomsresidential careresponsesuccesssymptom alleviationsymptom reductionsymptom reliefsynaptic circuitsynaptic circuitrytranslationtranslation to humanstranslational studytreatment programwithdrawal from alcohol
Description preview
Alcohol use disorders (AUDs) are disabling and prevalent conditions that affect almost one-third of Americans.
While initial treatments exist, relapse is common, making long-term recovery difficult. Given the high rates of
relapse, interventions that seek to prevent relapse have high potential impact. Animal models have shown that
the bed nucleus…
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