grant
Investigating GLI transcription factors as regulators of the pancreatic cancer microenvironment
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025Advanced DevelopmentAllelesAllelomorphsAntigenic DeterminantsAssayBasal Transcription FactorBasal transcription factor genesBinding DeterminantsBioassayBiological AssayCancer CauseCancer EtiologyCancer TreatmentCancersCell BodyCell Communication and SignalingCell LineCell LocomotionCell MigrationCell Migration AssayCell MovementCell SignalingCellLineCellsCellular MigrationCellular MotilityCessation of lifeChromatinClinical TrialsCre driverDataDeathDiagnosisDiseaseDisease ProgressionDisorderEpitopesErinaceidaeFamilyFibroblastsGLI Family GeneGLI Family ProteinGLI ProteinGLI geneGLI1GLI1 GeneGLI1 ProteinGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGeneticGenetic ModelsGenetic TranscriptionGlial Cell TumorsGlial NeoplasmGlial TumorGliomaGlioma Associated Oncogene Homolog 1 ProteinGlioma Associated Oncogene Homolog ProteinGlioma-Associated Oncogene HomologGlioma-associated oncogeneGrowthHealthHedgehog (Hh) signal transduction pathwayHedgehogsHumanImmuneImmunesIn VitroIncidenceIndividualIntracellular Communication and SignalingKnock-inLaboratoriesLigandsMacrophageMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsMigration AssayModern ManMurineMusMφNeoplasm MetastasisNeuroglial NeoplasmNeuroglial TumorNon-Polyadenylated RNAOrganoidsPancreasPancreas CancerPancreas NeoplasmsPancreas TumorPancreaticPancreatic CancerPancreatic TumorPathway interactionsPrimary NeoplasmPrimary TumorProteinsRNARNA ExpressionRNA Gene ProductsRegulationRibonucleic AcidRoleSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSpeedStrains Cell LinesSurvival RateT cell infiltrationT-CellsT-LymphocyteTestingTissue GrowthTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTransplantationTumor-DerivedUnited StatesWorkanti-cancer therapybiological signal transductioncancer metastasiscancer microenvironmentcancer progressioncancer therapycancer-directed therapycell motilitycultured cell lineeffective therapyeffective treatmentgenetic approachgenetic strategyglial-derived tumorglioma associated oncogene 1glioma associated oncogene family zinc finger 1hedgehog signalinghedgehog signaling pathwayhh signaling pathwayimprovedin vivoinhibitorknockinmalignancymouse modelmurine modelneoplasm progressionneoplasm/cancerneoplastic progressionneuroglia neoplasmneuroglia tumornovelontogenypancreatic cancer modelpancreatic malignancypancreatic neoplasiapancreatic neoplasmpancreatic tumor modelparacrinepathwaypatient prognosispharmacologicsmoothened signaling pathwaysocial rolethymus derived lymphocytetranscription factortransplanttransplant modeltumortumor cell metastasistumor growthtumor microenvironmenttumor progression
Description preview
PROJECT SUMMARY/ABSTRACT
Pancreatic cancer is a deadly human malignancy, with a five-year survival rate of 11%. Further, the incidence of
pancreatic cancer is rising and is projected to be the second-leading cause of cancer-related death in the United
States by 2030. The increasing occurrence of this disease, combined with the lack of effective…
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