grant
Investigating evolutionary antagonism between tumors and lymphocytes
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025Adaptive Immune SystemAddressAdoptedAntigenic DeterminantsAntigensArchitectureBar CodesBinding DeterminantsBody TissuesCancer PatientCancersCell BodyCell LineCellLineCellsCessation of lifeClonal EvolutionClonalityDeathDevelopmentDiseaseDisorderDistantDysfunctionEngineering / ArchitectureEnvironmentEpitopesEventEvolutionFamilyFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFunctional disorderGenomicsGoalsHNSCCHead and Neck Squamous Cell CarcinomaHumanImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune EvasionImmune SurveillanceImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune ToleranceImmune mediated therapyImmune responseImmune systemImmunesImmunologic DiseasesImmunologic ReceptorsImmunologic SurveillanceImmunologic ToleranceImmunological DiseasesImmunological DysfunctionImmunological ReceptorsImmunological System DysfunctionImmunologically Directed TherapyImmunosurveillanceImmunotherapyInnate Immune ResponseInvestigationLymph Node Reticuloendothelial SystemLymph node properLymphatic cellLymphatic nodesLymphocyteLymphocyticMHC ReceptorMajor Histocompatibility Complex ReceptorMalignant CellMalignant NeoplasmsMalignant TumorMapsMeasurementMetastasisMetastasis to Lymph NodesMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to Lymph NodesMetastatic TumorMetastatic Tumor to Lymph NodesMiceMice MammalsModelingModern ManMurineMusNeoplasm MetastasisOrganPatientsPhenotypePhysiopathologyPrimary NeoplasmPrimary TumorProcessReceptor ProteinResearch SpecimenSCCHNSamplingSecondary NeoplasmSecondary TumorSeriesSideSiteSpecificitySpecimenStrains Cell LinesStressSystemT cell receptor repertoire sequencingT cell receptor sequencingT-Cell Antigen ReceptorsT-Cell ReceptorT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT-StageTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTherapeutic InterventionTimeTissuesTravelTumor EscapeTumor Immune EscapeTumor stageVirus IntegrationWorkacquired immune systemadaptive immune responseantagonismantagonistanti-tumor immune responsearms racebarcodecancer cellcancer evasioncancer immune escapecancer immune evasioncancer metastasiscancer progressioncheck point blockadecheckpoint blockadeconventional therapyconventional treatmentcultured cell linedeliver vaccinesdevelop drug resistancedevelop therapydevelopmentaldrug resistance developmentexperimentexperimental researchexperimental studyexperimentsflow cytophotometryhead and neck squamous carcinomahead and neck squamous cell cancerhost responseimmune check point blockadeimmune checkpoint blockadeimmune evasiveimmune receptorimmune system responseimmune system toleranceimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune unresponsivenessimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunological paralysisimmunoresponsein vivoinsightintegration siteintervention developmentintervention therapylymph celllymph glandlymph node metastasislymph nodeslymphnodesmalignancymetastatic processmigrationneoplasm progressionneoplasm/cancerneoplastic progressionpathogenpathophysiologypressurereceptorresistance to therapyresistant to therapyresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell genomicssingle cell transcriptomic profilingsingle-cell RNA sequencingtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic resistancetherapy developmenttherapy resistantthymus derived lymphocytetraittranscriptomicstreatment developmenttreatment resistancetumortumor cell metastasistumor evasiontumor immune evasiontumor progressionvaccine deliveryviral genome integrationviral integrationvirus genome integration
Description preview
PROJECT SUMMARY
Metastasis accounts for the majority of cancer patient deaths and even though immune checkpoint blockade
has proven effective in many malignancies, metastatic disease remains resistant to therapy. Cancer
metastasis is an inefficient process, requiring cancer cells to disseminate from primary tumors to distant sites,
surviving the…
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