grant
Investigating Endocytic Mechanisms in Lysosome Rich Enterocytes
NIHUS FederalResearch GrantFY2025ANX2ANX2L4ANXA2ANXA2 geneActin-Activated ATPaseActin-Binding ProteinActinsActomyosinAdaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneApicalAssayBindingBioassayBiological AssayBiologyBrachydanio rerioCAL1HCapactin I Heavy ChainCell BodyCellsClathrinClathrin AdaptorsClathrin Assembly ProteinsClathrin-Associated AdaptorsClathrin-Associated ProteinsComplexDanio rerioDataDietary ProteinsDigestionElectron MicroscopyEndocytosisEnterocytesExhibitsF-ActinFilamentous ActinFishesGeneralized GrowthGeneticGrowthHumanINCO receptorImageInfant DevelopmentInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsIntestinalIntestinesKineticsKnowledgeLIP2LPC2DLengthLinkLipocortin IILysosomesMaintenanceMammaliaMammalsMediatingMembraneMiceMice MammalsMicroscopyModern ManMolecularMolecular InteractionMorphogenesisMotorMurineMusMyosin ATPaseMyosin Adenosine TriphosphataseMyosin AdenosinetriphosphataseMyosinsNeonatalOutcomeP36 Annexin IIPeptide DomainPhosphatasesPhosphatidyl InositolPhosphatidylinositolsPhosphohydrolasesPhosphoinositidesPhosphomonoesterasesPhosphoric Monoester HydrolasesPhysiologicPhysiologicalPhysiologyPopulationProcessProtein DomainsProteinsPtdInsPublishingRoleSeminalSpectrinStructureSystemTertiary Protein StructureTestingTissue GrowthTubularTubular formationVacuoleVertebrate AnimalsVertebratesVesicleZebra DanioZebra FishZebrafishabsorptionacetyl-LDL receptoracetylated LDL receptoradapter proteinamphiphysinapical membranebowelbrush border membranecoated pitcubilincubulingene manipulationgenetic manipulationgenetically manipulategenetically perturbimagingin vivoinfant nutritioninsightintrinsic factor-cobalamin receptormembrane structuremetermorphogenetic processnovelnutrient absorptionontogenypharmacologicpublic health relevancerecruitscaffoldscaffoldingscavenger receptorsegregationsocial rolestemuptakevertebratavitamin B12-intrinsic factor receptor
Description preview
ABSTRACT
Nutrient absorption in the neonatal mammalian gut relies on intracellular digestion by a population of enterocytes
known as vacuolated or neonatal enterocytes. Recently, we showed these cells are conserved between
zebrafish and mammals and are specialized in the uptake and digestion of dietary proteins. As these cells
possess a prominent…
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