grant
Investigating disseminated cancer cell clonal cooperation and immune control in dormancy and metastasis
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 21 May 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026AbscissionAdoptedAffectAgeAgonistAlveolar MacrophagesAlveolusAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryBSC-1 Cell Growth InhibitorBar CodesBasal Transcription FactorBasal transcription factor genesBasic Fibroblast Growth FactorBasic Fibroblast Growth Factor GeneBody TissuesBone-Derived Transforming Growth FactorBreastBronchial AlveolusCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCIF-BCartilage-Inducing Factor-BCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell ShapeCell SignalingCell-to-Cell InteractionCellsCirculationClinicalDCISDNA mutationDataDetectionDevelopmentDiseaseDisorderDown-RegulationDuctal Breast Carcinoma In SituDuctal Carcinoma In SituExcisionExtirpationFGF-2FGF2FGF2 geneFGFBFibroblast Growth Factor 2Fibroblast Growth Factor 2 GeneGAL1GSC-1GIGalectin 1General Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGeneticGenetic ChangeGenetic defectGenetic mutationGlioblastoma-Derived T-Cell Suppressor FactorGrowthHBGF-2Heparin-Binding Growth Factor 2Heparin-Binding Growth Factor Class IIImmuneImmune EvasionImmune SurveillanceImmune TargetingImmune mediated therapyImmunesImmunityImmunologic SurveillanceImmunologically Directed TherapyImmunosuppressantsImmunosuppressionImmunosuppression EffectImmunosuppressive AgentsImmunosuppressive EffectImmunosuppressive drugImmunosuppressive treatmentImmunosurveillanceImmunotherapyInfiltrationInflammatoryIntracellular Communication and SignalingIntraductal CarcinomaIntraductal Carcinoma of the BreastKnowledgeLGALS1Lineage TracingLungLung Respiratory SystemMacrophageMalignant CellMapsMediatingMetastasisMetastasis to the LungMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the LungMetastatic TumorMetastatic Tumor to the LungMilk Growth FactorMolecularMonitorMutationMφNeoplasm MetastasisNon-Infiltrating Ductal Breast AdenocarcinomaNon-Infiltrating Ductal Carcinoma of the BreastNon-Infiltrating Intraductal AdenocarcinomaNon-Infiltrating Intraductal Breast AdenocarcinomaNon-Invasive Ductal Breast AdenocarcinomaNon-Invasive Ductal Carcinoma of the BreastNon-Invasive Intraductal Breast AdenocarcinomaNoninfiltrating Intraductal CarcinomaOperative ProceduresOperative Surgical ProceduresOrganPD-L1 therapyPD-L1 treatmentPDL1 therapyPDL1 treatmentPathway interactionsPatientsPhasePhenotypePlatelet Transforming Growth FactorPolyerginPrimary NeoplasmPrimary TumorProductionPrognosisProstate Epithelial Cell Growth FactorProteinsPulmonary MacrophagesRecurrenceRecurrentRelapseRemovalRoleSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalT-CellsT-LymphocyteT-StageT8 CellsT8 LymphocytesTGF BTGF-Beta 2TGF-Beta2TGF-b2TGF-betaTGF-βTGF-β2TGFbetaTGFβTestingTimeTissue GrowthTissuesTranscription Factor Proto-OncogeneTranscription factor genesTransforming Growth Factor Beta 2Transforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTumor stageWorkaPD-L1 therapyaPD-L1 treatmentagesanti programmed cell death ligand 1 therapyanti programmed cell death ligand 1 treatmentanti programmed cell death protein ligand 1 therapyanti programmed cell death protein ligand 1 treatmentanti-PD-L1 therapyanti-PD-L1 treatmentanti-PDL1 therapyanti-PDL1 treatmentbFGFbarcodebiological signal transductioncancer cellcancer metastasiscancer progressioncell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingdevelopmentaleffective therapyeffective treatmentfunctional genomicsgenome mutationgenomic platformhuman dataimmune clearanceimmune eliminationimmune evasiveimmune suppressionimmune suppressive activityimmune suppressive agentimmune suppressive functionimmune suppressorimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenicimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimmunosuppressive substanceimmunosuppressorinhibitorinsightlung metastasismetastasize to the lungmouse modelmurine modelneoplasm progressionneoplastic progressionnovelontogenypathwaypreventpreventingprogramspulmonary metastasisresectionscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespecific biomarkerssurgerytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetranscription factortransforming growth factor beta2transforming growth factor β2tumortumor cell metastasistumor progressionαPD-L1 therapyαPD-L1 treatment
Description preview
SUMMARY. We revealed that cancer cells can disseminate from early stages of cancer progression and after
variable periods of dormancy they go on to form metastasis. Knowledge about how early DCCs (eDCCs) shape
metastatic progression, how they remain dormant and immune evasive for years and how they get reactivated,
is limited, but critically…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click