grant
Investigating Cognitive Control and Search in the Prefrontal-Hippocampal Network
Organization BETH ISRAEL DEACONESS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 15 Sept 2022Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AddressAlgorithmsAmmon HornBRAIN initiativeBehaviorBehavioralBrainBrain Nervous SystemBrain Research through Advancing Innovative Neurotechnologies initiativeCalciumCognitionCognitiveCommon Rat StrainsComputer ModelsComputerized ModelsComputing MethodologiesCornu AmmonisDiagnosisDiseaseDisorderDown-RegulationElectrophysiologyElectrophysiology (science)EncephalonEnvironmentEvaluationExperimental DesignsFeedbackFoundationsFutureGeneticGoalsHippocampusHumanImageImpairmentInvestigationKnowledgeLocationMachine LearningMeasurementMedialMediatingMemoryMental disordersMental health disordersMissionModelingModern ManMonitorNerve CellsNerve UnitNeural CellNeurobiologyNeurocyteNeuronsNeurophysiology / ElectrophysiologyPatientsPerformancePopulationPostdocPostdoctoral FellowPrefrontal CortexProcessPsyche structurePsychiatric DiseasePsychiatric DisorderRatRats MammalsRattusResearchResearch AssociateResearch ProposalsResolutionRodentRodent ModelRodentiaRodents MammalsRoleRunningSchizophreniaSchizophrenic DisordersTechniquesTechnologyTestingTherapeutic InterventionTrainingTranslational ResearchTranslational ScienceWorkbrain machine interfacecognitive controlcomputational methodologycomputational methodscomputational modelingcomputational modelscomputer based methodcomputer based modelscomputer methodscomputerized modelingcomputing methoddementia praecoxdesigndesigningelectrophysiologicalexperienceexperimentexperimental researchexperimental studyexperimentsflexibilityflexiblehippocampalimaginginnovateinnovationinnovativeintervention therapymachine based learningmentalmental illnessneuralneural correlateneural mechanismneural patterningneurobiologicalneuromechanismneuronalnoveloptogeneticspost-docpost-doctoralpost-doctoral traineepsychiatric illnesspsychological disorderresearch associatesresolutionsresponseschizophrenicsocial roletraining opportunitytranslation researchtranslational investigationtreadmillvirtualvirtual environmentvirtual realityvirtual world
Description preview
PROJECT SUMMARY/ABSTRACT
Multi-step planning is a fundamental basis of human cognition and its impairment in disorders like schizophrenia
disrupts goal-directed behavior in everyday situations. Essential to planning is the evaluation of alternative
actions based on an internal model of the environment, but the exact neural implementation of this…
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