grant
Investigating chromatin mechanisms using viral systems
Organization UNIVERSITY OF MIAMI SCHOOL OF MEDICINELocation CORAL GABLES, UNITED STATESPosted 1 Sept 2019Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3C-based approach3C-based assay3C-based method3C-based strategy3C-based technique3C-based technology3DAdenoviridaeAdenovirus ProteinAdenovirusesAntioncogene Protein p53AreaBiological FunctionBiological ProcessBiologyCMVCancer TreatmentCancersCell BodyCell CycleCell Division CycleCell NucleusCellsCellular Tumor Antigen P53CharacteristicsChromatinChromosomesCytomegalovirusDNA Molecular BiologyDevelopmentDiseaseDisorderElectron MicroscopyEnvironmentFundingGene TranscriptionGenetic TranscriptionGenomeHCMVHerpes SimplexHerpes Simplex InfectionsHerpes simplex diseaseHerpesviridaeHerpesvirus hominis diseaseHerpesvirusesHeterochromatinHistonesHumanImmunofluorescence MicroscopyInflammationInnovative TherapyMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMeasurementMethodologyMethodsModern ManMolecular BiologyNuclearNucleusOncoprotein p53P53Phosphoprotein P53Phosphoprotein pp53PositionPositioning AttributeProtein TP53RNA ExpressionRNA SplicingRegulationResearch ResourcesResolutionResourcesSalivary Gland VirusesSplicingStructureSystemTP53TP53 geneTRP53TechniquesTechnologyTestingTranscriptionTumor Protein p53Tumor Protein p53 GeneViralViral DiseasesVirusVirus AssemblyVirus DiseasesVirus Replicationanti-cancer therapybiological systemscancer therapycancer-directed therapychromatin conformation capturechromosome capturechromosome conformation capturecytomegalovirus groupdevelopmentaldynamic systemdynamical systemherpes simplex virus 1 infectionherpes simplex virus infectionherpes virusmalignancymarginalizationneoplasm/cancerp53 Antigenp53 Genesp53 Tumor Suppressorpathogenprotein p53resolutionsthree dimensionalviral assemblyviral infectionviral multiplicationviral replicationvirus host interactionvirus infectionvirus multiplicationvirus-induced disease
Description preview
PROJECT SUMMARY
The eukaryotic genome is compacted in a basic repeating structure called chromatin, the anomalous regulation
of which is characteristic of many diseases. In recent years, the technologies to study chromatin have leapt
forward, allowing us to investigate chromosome interactions in three dimensions. However, these methods rely
on…
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