grant
Investigating Autism-Related Gut Dysfunction with Human Enteric Neurons and Intestinal Organoids
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026ASDATAC sequencingATAC-seqATACseqAccelerationAddressAffectAnimal ModelAnimal Models and Related StudiesAnimalsAntisense AgentAntisense OligonucleotidesAssay for Transposase-Accessible Chromatin using sequencingAutismAutistic DisorderBrain DiseasesBrain DisordersCRISPR correctionCRISPR-based correctionCalciumCas9-based correctionCas9-mediated correctionCell BodyCell LineCell NucleusCellLineCellsChromatinClinicalCo-cultureCocultivationCocultureCoculture TechniquesComplexDNA mutationDataData SetDevelopmentDysfunctionEarly Infantile AutismEncephalon DiseasesEnteralEntericEnteric Nervous SystemExpression SignatureFunctional disorderFunctional impairmentGI Stem cellGastrointestinal DiseasesGastrointestinal MotilityGene ExpressionGene Expression ProfileGene TranscriptionGenesGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGliaGlial CellsHealth CareHeterogeneityHigh PrevalenceHigh Throughput AssayHumanImageImpairmentIn Situ HybridizationIn VitroIn vivo two-photon calcium imagingIndividualInduced pluripotent stem cell derived neuronsInfantile AutismIntestinalIntestinesIntracranial CNS DisordersIntracranial Central Nervous System DisordersKanner's SyndromeKnock-outKnockoutKnowledgeKolliker's reticulumLarge IntestineLinkMentorshipModelingModern ManMolecularMolecular FingerprintingMolecular ProfilingMotilityMutationNerve CellsNerve UnitNervous System PhysiologyNeural CellNeural CrestNeurocyteNeurogliaNeuroglial CellsNeurologic functionNeurological functionNeuron from iPSCNeuron from induced pluripotent stem cellsNeuronal DifferentiationNeuronsNon-neuronal cellNonneuronal cellNucleusOrganoidsPathway interactionsPatientsPhasePhysiologyPhysiopathologyPlayPostdocPostdoctoral FellowProceduresPublic HealthPublishingRNA ExpressionReportingResearchResearch AssociateRisk-associated variantRoleSYNGAP1Strains Cell LinesStructureSynaptic Ras GTPase Activating Protein 1SystemTechnologyTestingTranscriptionTransplantationWorkantisense oligoassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingautism spectral disorderautism spectrum disorderautistic childrenautistic individualsautistic peopleautistic spectrum disorderbowelcandidate identificationcell typechildren on the autism spectrumchildren with ASDchildren with autismchildren with autism spectrum disorderco-morbidco-morbiditycomorbiditycultured cell linedevelopmentaldisease phenotypeendophenotypeepigenomicsexperimentexperimental researchexperimental studyexperimentsgastrointestinalgastrointestinal disordergastrointestinal functiongastrointestinal stem cellgastrointestinal symptomgene expression patterngene expression signaturegenome mutationgut progenitorgut stem cellhiPSChigh throughput screeninghuman derived modelhuman derived platformhuman derived systemhuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshuman like modelhuman like platformhuman like systemhuman modelhuman specific alternativehuman specific modelhuman specific platformhuman specific systemhuman-based alternativehuman-based biological modelshuman-based modelhuman-based nonanimal modelshuman-based platformhuman-based researchhuman-based systemhuman-based toolshuman-centered modelhuman-centered platformhuman-centered researchhuman-centered systemhuman-focused researchhuman-relevant alternativehuman-relevant modelhuman-relevant platformhuman-relevant systemiPSiPS neuronsiPSCiPSC derived-neuronsiPSCsimagingin situ Hybridization Geneticsin situ Hybridization Staining Methodin vivo Modelin vivo calcium imagingindividuals on the autism spectrumindividuals on the spectrumindividuals with ASDindividuals with autismindividuals with autism spectrum disorderinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinduced pluripotent stem cell neuronsinduced pluripotent stem cells derived from patientsinduced pluripotent stem cells from patientsinducible pluripotent cellinducible pluripotent stem cellinsightintestinal epitheliumintestinal progenitorintestinal stem cellsknock-downknockdownlarge bowelmodel of animalmodel of humanmolecular profilemolecular signaturemutantnerve cementnervous system developmentnervous system functionneuralneuron developmentneuronalneuronal developmentneurons derived from induced pluripotent stem cellsneurons differentiated from induced pluripotent stem cellsorganoid transplantationpathophysiologypathwaypatient derived human iPSpatient derived human iPSCpatient derived human induced pluripotent stem cellpatient derived iPSpatient derived iPSCpatient derived induced pluripotent cellspatient derived induced pluripotent stem cellspatient-derived pluripotent stem cellspeople on the autism spectrumpeople with ASDpeople with autismpeople with autism spectrum disorderpost-docpost-doctoralpost-doctoral traineeprogenitor cell modelprogenitor cell nicheprogenitor modelprogenitor nicheproliferation capabilityproliferation capacityproliferation potentialproliferative capabilityproliferative capacityproliferative potentialresearch associatesrisk allelerisk generisk genotyperisk locirisk locusrisk variantscATAC sequencingscATAC-seqscRNA sequencingscRNA-seqsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell genomicssingle cell sequencing assay for transposase accessible chromatinsingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsocial rolestem and progenitor cell modelstem and progenitor cell nichestem cell based modelstem cell derived modelstem cell modelstem cell nichesynapse functionsynaptic functiontranscriptional profiletranscriptional signaturetransplant
Description preview
Project Summary
Gastrointestinal (GI) disorders are among the most common comorbidities in patients with Autism Spectrum
Disorder (ASD). The Enteric Nervous System (ENS), composed of neurons (ENs) and glia, is crucial in regulating
various aspects of gut physiology. Animal models show GI motility impairments linked to altered expression of…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click