grant
Investigating an uncharacterized mitochondrial protein in cellular and hepatic physiology
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 15 Jul 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025Abnormal Assessment of MetabolismAdult-Onset Diabetes MellitusAdvisory CommitteesAffectAmino AcidsAutoregulationAwardBiogenesisBiologyBlood SerumBostonCRE RecombinaseCatabolismCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCellular biologyChildren's HospitalCo-ImmunoprecipitationsCultured CellsDataData BasesDatabasesDiseaseDisorderDoctor of MedicineDoctor of PhilosophyDysfunctionElectron TransportEnterobacteria phage P1 Cre recombinaseEnzyme GeneEnzymesExhibitsFatty AcidsFellowshipFlavoproteinsFunctional disorderFundingFutureGenesGenotoxinsHealthHepaticHepatic CellsHepatic DisorderHepatic Parenchymal CellHepatic mitochondriaHepatocyteHereditary Metabolic DisorderHexose Monophosphate ShuntHistologyHomeostasisHumanImmunoblottingImpairmentInborn Errors of MetabolismIntermediary MetabolismInternationalInvestigationInvestigatorsIsoleucineKO miceKetosis-Resistant Diabetes MellitusKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeL-ValineLearningLifeLinkLiverLiver CellsLiver Function TestsLiver MitochondriaLiver diseasesM.D.ManuscriptsMaturity-Onset Diabetes MellitusMentorsMentorshipMetabolicMetabolic DiseasesMetabolic DisorderMetabolic PathwayMetabolic ProcessesMetabolic StudiesMetabolismMetabolism StudiesMiceMice MammalsMitochondriaMitochondrial ProteinsModern ManMurineMusMutagensNIDDMNational Institutes of HealthNatureNeonatalNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNull MouseOrganOrganellesOrigin of LifePathologyPathway interactionsPediatric HospitalsPediatricsPentose Phosphate PathwayPentose Phosphate ShuntPentose ShuntPentosephosphate PathwayPentosephosphate ShuntPh.D.PhDPhosphatesPhysiciansPhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPhysiopathologyPlayPostdocPostdoctoral FellowPrintingProductionProteinsProteomeRegulationResearchResearch AssociateResearch PersonnelResearch ProposalsResearch ResourcesResearchersResidenciesResourcesRespirationRespiratory ChainRoleScientistSerumSlow-Onset Diabetes MellitusStable Diabetes MellitusSubcellular ProcessSystemT2 DMT2DT2DMTask ForcesTechniquesTestingThesaurismosisTrainingType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUnited States National Institutes of HealthValineWestern BlottingWestern ImmunoblottingWorkadult onset diabetesadvisory teamaminoacidbacteriophage P1 recombinase Crebioplexcareercareer developmentcell biologydata baseelectron transferexperimentexperimental researchexperimental studyexperimentsgenotoxic agentglutaric acidemiaglutaric aciduriaglutaricacidemiahepatic body systemhepatic diseasehepatic metabolismhepatic organ systemhepatopathyhuman diseasein silicoinborn metabolism disorderinorganic phosphateinsightinterestketosis resistant diabetesliver disorderliver metabolismmaturity onset diabetesmetabolic abnormality assessmentmetabolism disordermitochondrialmitochondrial dysfunctionmouse modelmultidisciplinarymurine modelneonatal periodpathophysiologypathwayperinatal medicineperoxisomepost-docpost-doctoralpost-doctoral traineeprotein blottingresearch associatesrespiratory mechanismskillssocial rolestable isotopesynthetic polymer Bioplextype 2 DMtype II DMtype two diabetes
Description preview
PROJECT SUMMARY/ABSTRACT
This proposal details a career training plan for Dr. Walter Chen, a neonatologist at UT Southwestern, to
become an independent physician-scientist studying metabolic organelles and how they contribute to liver
homeostasis and disease (e.g., inborn errors of metabolism [IEMs]). Dr. Chen received his M.D. and Ph.D.
degrees…
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