grant
Intrinsic Ribosomal Decoding Center Methylation and the Bacterial Antibiotic Response
NIHUS FederalResearch GrantFY2025AffectAminoglycoside resistanceAminoglycoside resistantAminoglycosidesAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibiotic susceptibilityAntibioticsAntimicrobial ResistanceAssayBacteriaBacteria resistanceBacteria resistantBacterial Antibiotic ResistanceBacterial resistantBindingBioassayBiologicalBiological AssayBypassCessation of lifeChemicalsComplementComplement ProteinsCryo-electron MicroscopyCryoelectron MicroscopyCutting-edge antimicrobialD-RiboseDeathDevelopmentDistantDockingDrug Binding SiteDrugsE coliE. coliEC 2.1.1Electron CryomicroscopyEnzyme GeneEnzymesEscherichia coliFutureGeneralized GrowthGenetics-MutagenesisGrowthHealthHousekeepingHouseworkImpairmentIn VitroInvestigatorsMedicationMessenger RNAMethylationMethyltransferaseMicrobiologyMiscellaneous AntibioticModificationMolecularMolecular Dynamics SimulationMolecular InteractionMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantMutagenesisMutagenesis Molecular BiologyNon-Polyadenylated RNAPharmaceutical PreparationsPlayPositionPositioning AttributePredispositionProcessPublic HealthRNARNA Gene ProductsResearch PersonnelResearchersResistanceResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistance to antibioticsResistant to Multiple DrugResistant to antibioticsResistant to multi-drugResistant to multidrugResolutionRibonucleic AcidRiboseRibosomal RNARibosomesRoleScientistSeriesSiteStructureSurfaceSusceptibilityTestingTimeTissue GrowthTrainingWorkanti-microbial resistantantibiotic drug resistanceantibiotic resistantantibiotic resistant bacteriabacterial antibiotic resistantbacterial resistancebacterial resistance to antibioticbasebasesbiologiccombatcomplementationcryo-EMcryoEMcryogenic electron microscopydesigndesigningdevelopmentaldrug developmentdrug sensitivitydrug/agentenzyme activityenzyme mechanismexperimentexperimental researchexperimental studyexperimentsfuture antimicrobialglobal healthinsightmRNAmethylasemolecular dynamicsmulti-drug resistantmultidrug resistantnew generation antimicrobialnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenyrRNAresistance against aminoglycosideresistance strainresistance to Bacteriaresistance to Bacterialresistance to aminoglycosideresistance to anti-microbialresistantresistant strainresistant to Bacteriaresistant to Bacterialresistant to aminoglycosideresistant to antimicrobialresolutionsresponsesocial roletransmethylase
Description preview
PROJECT SUMMARY/ABSRACT
Bacterial antibiotic resistance is a substantial public health threat, currently responsible for more than one million
deaths globally and predicted to escalate dramatically in the coming decades. As multidrug resistant strains
continue to emerge, it is imperative that we identify new antibiotic targets, design new…
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