grant
Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent Rheumatic Heart Disease: A non-inferiority randomized trial. (GOALIE)
Organization CINCINNATI CHILDRENS HOSP MED CTRLocation CINCINNATI, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20260-11 years old5 year old5 years of ageAbsenteeism at workAcuteAcute Articular RheumatismsAdherenceAffectAntibiotic AgentsAntibiotic DrugsAntibiotic PremedicationAntibiotic ProphylaxisAntibioticsBacteriaBioavailabilityBiological AvailabilityCessation of lifeChildChild CareChild YouthChildren (0-21)ClinicalCollaborationsCommunitiesConfidence IntervalsCost MeasuresCost metricsDataDeathDetectionDiagnosisDiseaseDisease ProgressionDisorderEchocardiogramEchocardiographyEconomicsEffectivenessEligibilityEligibility DeterminationEmployee AbsenteeismEndemic DiseasesEnrollmentEnsureEnteralEntericGuidelinesHealthHealth Care ProvidersHealth PersonnelHealth systemHeart Valve DiseasesHigh PrevalenceHistoryInfrastructureInjectableInternationalIntramuscularIntramuscular InjectionsLMICLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingMethodsMiscellaneous AntibioticOralOutcomePainPainfulParentsPatient Outcomes AssessmentsPatient Reported MeasuresPatient Reported OutcomesPatientsPenicillinsPersonsPhysiologic AvailabilityPoliciesPositionPositioning AttributeProphylactic treatmentProphylaxisProtocolProtocol ScreeningProtocols documentationPublic HealthPuericultureQALYQOLQuality of lifeQuality-Adjusted Life ExpectancyQuality-Adjusted Life YearsRandomization trialRandomizedRandomized, Controlled TrialsRecording of previous eventsReportingResearch ResourcesResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingResourcesRheumatic FeverRheumatic Heart DiseaseSchoolsStructureTimeTrainingTransthoracic EchocardiographyTravelUgandaValvular Heart DiseasesValvular Heart Disorderage 5age 5 yearsassess effectivenesscardiac valve diseasecardiac valve disordercardiac valvular diseaseclinical practicecomparable efficacycomparative efficacycompare efficacycostcost effectivenesscost measurementcost-effectiveness indicescost-effectiveness ratiodegenerative valvular heart diseasedetermine effectivenesseconomiceconomic analysiseconomic assessmenteconomic evaluationeffectiveness assessmenteffectiveness evaluationenrollevaluate effectivenessexamine effectivenessexperiencefive year oldfive years of agehealth care personnelhealth care workerhealth providerhealth related quality of lifehealth staffhealth workershealth workforcehealthcare employeeshealthcare staffhealthcare workforceheart sonographyheart valve disorderhistoriesimproved outcomeincremental cost-effectivenessincrementally cost effectiveintramuscular drug administrationkidslow and middle-income countriesmedical care providersmedical personnelmissing workparentpatient barrierspatient-level barriersprematureprematuritypreventpreventingrandomisationrandomizationrandomized control trialrandomized trialrandomly assignedrecruitsatisfactionscale upscreeningscreeningsstandard of caresystem-level barrierstreatment providertrial comparingyoungster
Description preview
PROJECT SUMMARY ABSTRACT
Rheumatic heart disease (RHD) remains a high prevalence condition in low-and-middle-income countries,
currently affecting at least 40 million people, many of whom suffer premature death. Most patients with RHD
present late, missing the opportunity to benefit from secondary antibiotic prophylaxis. Screening
echocardiography…
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