grant
Intestinal regulation of exercise performance
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 16 Feb 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2026AddressAfferent NeuronsAlimentary CanalAmidesAnimalsAutomobile DrivingBehaviorBehavioralBrainBrain Nervous SystemCB1CB1 ReceptorCB1RCNR1 geneCancersCannabinoid Receptor CB1Cardiovascular DiseasesCell BodyCell Communication and SignalingCell SignalingCellsChronic DiseaseChronic IllnessCommunicationCorpus StriatumCorpus striatum structureD1 receptorDataDegenerative Neurologic DisordersDevelopmentDiabetes MellitusDietDietary InterventionDigestive TractDiseaseDisorderDopamineDopamine D1 ReceptorElementsEncephalonEndocannabinoidsEndogenous CannabinoidsExerciseExercise PhysiologyFatty AcidsFutureGI TractGI microbiomeGI microbiotaGastrointestinal TractGastrointestinal microbiotaGastrointestinal tract structureGene ClusterGene ExpressionGeneral PopulationGeneral PublicGeneral TaxonomyGenesGeneticGerm-FreeGnotobioticGnotobioticsGoalsHabitsHealth BenefitHumanHydroxytyramineImmediate-Early GenesIndividualInflammatoryInterventionIntestinalIntestinesIntracellular Communication and SignalingInvestigationLife StyleLifestyleLinkLiteratureMalignant NeoplasmsMalignant TumorMeasurementMeasuresMediatingMetabolicMiceMice MammalsMicrobiomicsModern ManModernizationMolecularMonitorMotivationMurineMusNerve CellsNerve DegenerationNerve Impulse TransmissionNerve TransmissionNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronal TransmissionNeuronsNeurosciencesNutrition InterventionsNutritional InterventionsOperative ProceduresOperative Surgical ProceduresOutputPerformancePeripheralPhysical activityPopulationPsychological reinforcementPublishingRegulationReinforcementResearchRewardsRoleSensorySensory NeuronsSignal TransductionSignal Transduction SystemsSignalingStriate BodyStriatumSurgicalSurgical InterventionsSurgical ProcedureTRPV1TRPV1 geneTaxonomyTestingTherapeuticWorkalimentary tractaxon signalingaxon-glial signalingaxonal signalingbiological signal transductionbowelbrain controlbrain pathwaycannabinoid receptor 1cannabinoid receptor type 1cannabinoid type 1cardiovascular disordercardiovascular riskcardiovascular risk factorchronic disordercollaborative approachcommensal floracommensal microbescommensal microbiotacommensal microfloradegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldiabetesdiet interventiondietarydietsdigestive canaldigestive tract microbiomedrivingenteric microbial communityenteric microbiomeenteric microbiotaexperimentexperimental researchexperimental studyexperimentsgastrointestinalgastrointestinal microbial floragastrointestinal microbiomeglia signalingglial signalinggut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut to brain axisgut-associated microbiomegut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalinghost microbiomeimprovedinnovateinnovationinnovativeinsightintestinal biomeintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloralenslenseslife style interventionlife-style factorlifestyle factorslifestyle interventionmalignancymembermicrobialmicrobial colonizationmicrobial consortiamicrobial floramicrobiomemicrobiome researchmicrobiome sciencemicrobiome studiesmicrobiotamicrofloramultispecies consortianeoplasm/cancerneoplasticnerve signalingneuralneural degenerationneural signalingneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronalneuronal degenerationneuronal signalingneurophysiologicalneurophysiologyneurotransmissionnew approachesnovel approachesnovel strategiesnovel strategypharmacologicpre-clinicalpreclinicalpreventpreventingrational designresponsesedentarysocial rolestriatalsurgerytooltransient receptor potential cation channel V1willingness
Description preview
SUMMARY
Exercise is an extremely effective lifestyle intervention that dramatically lowers the risk for cardiovascular,
metabolic, neoplastic, chronic inflammatory, and neurodegenerative diseases. Despite these beneficial effects,
the modern human lifestyle is highly sedentary and new approaches to understanding and improving exercise
performance…
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