grant
Interspecies microbial interactions in CKD
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 15 May 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY202621+ years old3-indolylacetic acidAbscissionAccelerationAdultAdult HumanAffectAmericanAminesAnaerobic BacteriaBindingBionomicsCatabolismCessation of lifeChronic DiseaseChronic IllnessChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinical ManagementClinical TreatmentColiform BacilliColonDataDeathDeteriorationDialysisDialysis procedureDisease ProgressionE coliE. coliEcologyEndogenous Nitrate VasodilatorEndothelium-Derived Nitric OxideEnteric BacteriaEnterobacteriaEnterobacteriaceaeEnvironmentEscherichia coliExcisionExtirpationGI microbiotaGastrointestinal microbiotaGeneralized GrowthGenesGnotobioticGnotobioticsGoalsGrowthHemodialysesHemodialysisIES cpdINOSImmune responseImpairmentIndicanIndolesIndoxyl SulfateInducible Nitric Oxide SynthaseInterventionIntervention StrategiesIntestinalIntestinesInvestigatorsKidney FailureKidney InsufficiencyL-TryptophanLevotryptophanLinkMacrophage Nitric Oxide SynthaseMedicalMicrobeMicrobiomicsModelingMolecularMolecular InteractionMononitrogen MonoxideMorbidityMucosaMucosal TissueMucous MembraneNO3-NOS2NOS2ANOS2A geneNOS2A, Inducible, HepatocyteNitratesNitric OxideNitric Oxide Synthase 2ANitrogen MonoxideNitrogen ProtoxideNutritionalOutcomeOxidesPhysiologicPhysiologicalPlasma ProteinsPopulationProductionRemovalRenal FailureRenal InsufficiencyRenal functionResearchResearch PersonnelResearchersRespirationShapesSulfateSuperoxide AnionSuperoxide RadicalSuperoxidesSurgical RemovalTestingTissue GrowthToxinTranslatingTryptophanUremiaWorkadulthoodamineanaerobebeta-indoleacetic acidbowelchronic disorderchronic kidney diseaseclinical interventionclinical therapydamage to kidneydialysis therapydysbacteriosisdysbiosisdysbioticendothelial cell derived relaxing factorenteric microbial communityenteric microbiotafecal microbial communityfecal microbiotagastrointestinal microbial floragut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahost responsehost-associated microbeshost-associated microbial communitieshost-associated microbiotahost-associated microorganismsimmune system responseimmunoresponseindole acetic acidindole-3-acetic acidindoleacetic acidindolyl-3-acetic acidinducible expressioninducible gene expressioninnovateinnovationinnovativeinsightinterestintestinal floraintestinal microbiotaintestinal microfloraintestinal tract microflorakidney damagekidney functionmembermicrobial consortiamicrobial floramicrobial imbalancemicrobial interactionmicrobiomemicrobiome researchmicrobiome sciencemicrobiome studiesmicrobiotamicrobiota compositionmicrofloramicroorganism interactionmortalitymouse modelmultispecies consortiamurine modelnitratenovelnutritiousontogenypreventpreventingrational designrenal damageresectionrespiratory mechanismtrial regimentrial treatmenturemia of renal origin
Description preview
ABSTRACT
Chronic kidney disease (CKD) is a gradual loss of kidney function, which affects an
estimated 37 million American adults, resulting in 14.6 deaths per 100,000 population. Once
kidney damage occurs, it impairs removal of uremic toxins, leading to further deterioration of
physiological functions and progression of renal failure.…
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