grant
Interrogating Type I Interferon signaling in breast cancer brain metastasis
Organization RESEARCH INST OF FOX CHASE CAN CTRLocation PHILADELPHIA, UNITED STATESPosted 1 Dec 2023Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AddressAlpha-Beta-Omega Interferon Receptor-1Animal ModelAnimal Models and Related StudiesAntiviral Protein Alpha TypeAstrocytesAstrocytusAstrogliaAttenuatedBlood monocyteBrainBrain MetastasisBrain Nervous SystemBreast CancerCCL2CCL2 geneCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCancersCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsCessation of lifeCheckpoint inhibitorChemokine Receptor GeneChemokine, CC Motif, Ligand 2Chemotactic CytokinesChronicClinicClinicalCo-cultureCocultivationCocultureCoculture TechniquesCombined Modality TherapyComplexDataDeathDevelopmentDiseaseDisorderDisseminated Malignant NeoplasmDistalEncephalonEndogenous Interferon BetaFibroblast InterferonGeneralized GrowthGrowthHomologous Chemotactic CytokinesHuIFN-Alpha-RecIFNIFN activationIFN-βIFNARIFNAR1IFNAR1 geneIFNBRIFNbIFRCImaging ProceduresImaging TechnicsImaging TechniquesImmuneImmune checkpoint inhibitorImmune infiltratesImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIn VitroIncidenceInfiltrationIntercrinesInterferon ActivationInterferon Alpha-Beta Receptor Alpha ChainInterferon Type IInterferon-βInterferonsIntracellular Communication and SignalingInvadedKO miceKnock-out MiceKnockout MiceLesionLocationMCAFMCP-1MCP1Malignant Breast NeoplasmMalignant CellMalignant NeoplasmsMalignant TumorMarrow monocyteMediatingMedicalMetastasisMetastasizeMetastatic CancerMetastatic LesionMetastatic Malignant NeoplasmMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the BrainMetastatic TumorMetastatic Tumor to the BrainMetastatic breast cancerMetastatic malignant neoplasm to brainMiceMice MammalsModelingMolecularMonocyte Chemoattractant Protein-1Monocyte Chemotactic Protein-1Monocyte Chemotactic and Activating FactorMonocyte Chemotactic and Activating ProteinMonocyte Chemotactive and Activating FactorMonocyte Secretory Protein JEMultimodal TherapyMultimodal TreatmentMurineMusMyelogenousMyeloidMyeloid CellsNatural Interferon BetaNatural human interferon betaNeoplasm MetastasisNull MouseOrganPathway interactionsPatientsPre-Clinical ModelPreclinical ModelsProcessProductionRNA SeqRNA sequencingRNAseqReceptor ProteinRecurrent Malignant NeoplasmRecurrent Malignant TumorReporterResearchResearch ProposalsSCYA2SIS cytokinesSYS-TXSamplingSecondary NeoplasmSecondary TumorShapesSignal InductionSignal TransductionSignal Transduction SystemsSignalingSmall Inducible Cytokine A2Stromal CellsStudy modelsSurvival RateSystemic TherapyT8 CellsT8 LymphocytesTestingTherapeuticTherapeutic EffectTimeTissue GrowthVisualizationWorkangiogenesisastrocytic gliaattenuateattenuatesbiological signal transductionbrain cellbrain micrometastasiscancer cellcancer metastasiscancer recurrencechemoattractant cytokinechemokinechemokine receptorchemotherapycombination therapycombined modality treatmentcombined treatmentdevelopmentaldruggable targeteffective therapyeffective treatmentefficacy testingexperimentexperimental researchexperimental studyexperimentsifnar1 gene productimmune cell infiltrateimmune check point inhibitorimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedin vivoinhibitorinsightmalignancymalignant breast tumormetastatic breast tumormetastatic mammary cancermetastatic mammary tumormetastatic processmodel of animalmonocytemouse modelmulti-modal therapymulti-modal treatmentmurine modelneoplasm/cancernew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnotchnotch proteinnotch receptorsnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetontogenyoptimal therapiesoptimal treatmentspathwaypre-clinicalpreclinicalreceptorreconstructionrecruitresponseside effectspatial and temporalspatial temporalspatiotemporaltherapeutic targettherapeutically effectivetranscriptome sequencingtranscriptomic sequencingtumortumor cell metastasistumorigenictype I IFN receptortype I interferon receptor
Description preview
PROJECT SUMMARY
The brain is one of the common organs for breast cancer recurrence. Breast cancer brain metastasis is
increasingly becoming a significant clinical problem due to its rising incidence and limited efficacy of existing
systemic therapies. Metastasis is the consequence of favorable interactions between the invaded cancer cells
and the…
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