grant
Interrogating immune response and coronavirus infection in a migratory bat model
Organization UNIVERSITY OF OKLAHOMALocation NORMAN, UNITED STATESPosted 15 May 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026Acute-Phase ReactionAcute-Phase ResponseAcute-Phase StateAffectAnti-viral ResponseAssayBackBatsBioassayBioinformaticsBiologic ModelsBiological AssayBiological ModelsBirthBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood SampleBlood VolumeBlood specimenCOBRECOVID detectionCOVID-19 detectionCOVID-19 predispositionCOVID-19 susceptibilityCOVID-19 vulnerabilityCOVID19 detectionCareer MobilityCenter of Biomedical Research ExcellenceCenters of Research ExcellenceChiropteraChronicClinicalCoronaviridaeCoronaviridae InfectionsCoronavirusCoronavirus InfectionsCoronavirus disease 2019 predispositionCoronavirus disease 2019 susceptibilityCoronavirus disease 2019 vulnerabilityCouplingCytosine PolynucleotidesDNADataData Science CoreData Science Resource CoreDemographyDeoxyribonucleic AcidDevelopmentDifferential Gene ExpressionDiseaseDisorderDorsumFecesFundingFutureGene ExpressionGene ProteinsGenesGenetic MarkersHCoVHealthHumanIFNImmuneImmune MarkersImmune ToleranceImmune responseImmunesImmunochemical ImmunologicImmunologicImmunologic MarkersImmunologic ToleranceImmunologicalImmunologicallyImmunologicsImmunomodulationImpairmentInfectionInfrastructureInnate Immune SystemInterferonsInvestigatorsJob LocationJob PlaceJob SettingJob SiteLaboratoriesLactationLymphatic cellLymphocyteLymphocyticLyssavirusMarrow NeutrophilMath ModelsMentorsMexicanMexicoModel SystemModelingModern ManMonitorMovementNational Institutes of HealthNeutrophilic GranulocyteNeutrophilic LeukocyteNon-Polyadenylated RNANorth AmericaNucleic AcidsOklahomaOralOrthocoronavirinaeParturitionPathogenicityPhysiologicPhysiologicalPilot ProjectsPoly CPoly I-CPolycytidylic AcidsPolyinosinic-Polycytidylic AcidPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPredisposed to COVID-19Predisposed to SARS-CoV-2Predisposed to Severe acute respiratory syndrome coronavirus 2PredispositionPrevalenceProtein Gene ProductsProteinsProteomicsProtocolProtocols documentationRNARNA Gene ProductsRNA Virus InfectionsRNA VirusesRNA viral infectionRT-PCRRadarReceiver Operating CharacteristicsReceiver Operator CharacteristicsRectumRelapseResearch PersonnelResearchersReverse Transcriptase Polymerase Chain ReactionRibonucleic AcidRiskRouteRunningSARS-CoV-2 detectionSARS-CoV-2 predispositionSARS-CoV-2 susceptibilitySARS-CoV-2 vulnerabilitySalineSaline SolutionSalivaSamplingSeasonal CycleSeasonal VariationsSeasonsSevere acute respiratory syndrome coronavirus 2 predispositionSevere acute respiratory syndrome coronavirus 2 susceptibilitySevere acute respiratory syndrome coronavirus 2 vulnerabilitySiteStressSurgical suturesSusceptibilitySuturesSwabSystemTailTechnologyTestingTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTransmissionUnited States National Institutes of HealthViralViral DiseasesViral SheddingVirulentVirusVirus DiseasesVirus ReplicationVirus SheddingWorkWork LocationWork PlaceWork-SiteWorkplaceWorksiteZoonosesZoonoticZoonotic Infectionanti-viral immunityantigen challengeantiviral immunitybat-bornebatbornebeta CoVbeta coronavirusbetaCoVbetacoronavirusbiological sex as a modifierbody movementcandidate biomarkercandidate identificationcandidate markercareer advancementcareer transitioncomputational pipelinescorona viruscoronavirus detectioncoronavirus disease 2019 detectioncoronavirus disease detectiondata integrationdetect COVIDdetect COVID-19detect COVID19detect SARS-CoV-2detect coronavirusdetect coronavirus diseasedetect severe acute respiratory syndrome coronavirus 2developmentalengineered immune systemfallsfield based datafield learningfield studyfield testgene biomarkergene expression biomarkergene markergene signature biomarkergenetic biomarkergraduate studenthomopolymer 5'-Cytidylic acidhost responsehuman CoVhuman corona virushuman coronavirusimmune engineeringimmune modulationimmune regulationimmune system responseimmune system toleranceimmune unresponsivenessimmune-based biomarkersimmunoengineeringimmunologic reactivity controlimmunological biomarkersimmunological markersimmunological paralysisimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponsein vivoinfection mouthinnovateinnovationinnovativeinsightlactatinglactationallight weightlightweightlymph cellmachine learned algorithmmachine learning algorithmmachine learning based algorithmmathematic modelmathematical modelmathematical modelingmigrationneutrophilnoveloral infectionoral infectiouspathogenpilot studypoly I:Cpoly ICpoly(I:C)post-doctoral trainingpredisposed to Coronavirus disease 2019protein biomarkersprotein markersresponsereverse transcriptase PCRsample collectionsevere acute respiratory syndrome coronavirus 2 detectionsexsex as a biological factorsex as a biological measuresex as a biological risk factorsex as a biological variablesex as a biological variancesex as a biologically significant variablesex as a fundamental variablesimulationspatial and temporalspatial temporalspatiotemporalspecimen collectionstoolstressorsuccesssusceptible to COVID-19susceptible to Coronavirus disease 2019susceptible to SARS-CoV-2susceptible to Severe acute respiratory syndrome coronavirus 2transcriptomicstransmission processviral infectionviral multiplicationviral replicationvirus infectionvirus multiplicationvirus-induced diseasevulnerable to COVID-19vulnerable to Coronavirus disease 2019vulnerable to SARS-CoV-2vulnerable to Severe acute respiratory syndrome coronavirus 2work settingβ CoVβ coronavirusβCoV
Description preview
PROJECT SUMMARY
Bats harbor many zoonotic viruses, including both genera of coronaviruses (CoVs) pathogenic in humans (α-
and β-CoVs). Limited evidence to-date suggests that periods of active infection in bats—and thus opportunities
to transmit zoonotic viruses to humans—are driven by stressors that modulate immunological tolerance of
infection…
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