grant
Interrogating function, regulation, and interactions in a clade of prevalent human gut microbes
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 1 Aug 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025ASCVDAffectAtherosclerosisAtherosclerotic Cardiovascular DiseaseBiochemicalCase-Base StudiesCase-Comparison StudiesCase-Compeer StudiesCase-Referent StudiesCase-Referrent StudiesCase/Control StudiesCommunitiesDataDevelopmentDistantDrugsEnvironmentFunctional MetagenomicsFutureGene ExpressionGeneralized GrowthGenesGrowthHealthHumanImmunomodulationIn VitroIntermediary MetabolismInterventionKnowledgeLaboratoriesLeadLinkMediatingMedicationMetabolicMetabolic ControlMetabolic ProcessesMetabolismMetagenomicsMicrobeMicrobiomicsModern ManNutrientOutputPb elementPharmaceutical PreparationsPhysiologicPhysiologicalProcessRegulationResearchTissue Growthatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebacteria in the gutcase-controlled studiesdata diversitydevelopmentaldietarydiverse datadrug/agentgene functiongut bacteriagut microbesgut microbial speciesheavy metal Pbheavy metal leadimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimprovedin vivointestinal microbesmicrobialmicrobial interactionmicrobiomemicrobiome researchmicrobiome sciencemicrobiome studiesmicroorganism interactionmodel organismontogenypathogenstressortargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettool
Description preview
PROJECT SUMMARY/ABSTRACT
Human-associated microbes are causally linked to processes as diverse as immunomodulation, protection
against pathogens, and atherosclerosis. Many of these links are mediated through biochemical transformations
of dietary, drug, or host compounds. This makes the microbiome a promising therapeutic target, especially as
we…
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