grant
Interrogating a white matter degeneration-specific astrocyte reactivity state and its role in governing repair-associated microglia specification and function.
Organization CEDARS-SINAI MEDICAL CENTERLocation LOS ANGELES, UNITED STATESPosted 1 Apr 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026ATAC sequencingATAC-seqATACseqAbscissionAcuteAcute DiseaseAssay for Transposase-Accessible Chromatin using sequencingAstrocytesAstrocytusAstrogliaAttenuatedAxonBiological MarkersBody TissuesCNS InjuryCNS Nervous SystemCNS degenerationCell BodyCell Communication and SignalingCell NucleusCell SignalingCell to Cell Communication and SignalingCell-Cell SignalingCellsCentral Nervous SystemCharacteristicsChromatinChromatin StructureChronicChronic DiseaseChronic IllnessCommunicationCuesDataDegenerative Neurologic DisordersDeteriorationDiseaseDisease ProgressionDisorderDisseminated SclerosisEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExcisionExhibitsExtirpationGene TranscriptionGenesGeneticGenetic TranscriptionHortega cellImmuneImmunesIn VitroInflammationInflammatoryInflammatory ResponseInnate Immune ResponseIntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingIschemiaKO miceKnock-out MiceKnockout MiceLesionLinkLow Molecular Weight Nuclear RNAMacrophageMediatingMethodsMiceMice MammalsMicrogliaModelingMolecularMolecular FingerprintingMolecular ProfilingMotilityMultiple SclerosisMurineMusMyelinMφNervous System Degenerative DiseasesNervous System InjuriesNervous System TraumaNervous System damageNeural Degenerative DiseasesNeural degenerative DisordersNeuraxisNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurological DamageNeurological InjuryNeurological traumaNoduleNucleusNull MousePathway interactionsPeripheralPhagocytesPhagocytic CellPhagocytosisPhenotypeProductionRNA ExpressionReceptor ProteinRecoveryRecovery of FunctionRegulationRegulatory PathwayRemovalResearchResolutionRoleShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingSmall Molecular Weight RNASmall Nuclear RNASpecific qualifier valueSpecifiedSurgical RemovalSystemTestingTherapeuticTimeTissuesTranscriptionTransgenic OrganismsValidationWorkacute disease/disorderacute disorderamebocyteanalysis pipelineassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingastrocytic gliaattenuateattenuatesaxonal degenerationbio-markersbiologic markerbiological signal transductionbiomarkercancer microenvironmentcell typecentral nervous system degenerationcentral nervous system injurychronic disorderdegenerative axondegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelop therapyepigeneticallyexperimentexperimental researchexperimental studyexperimentsfunctional recoverygitter cellhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsimproved outcomein vivoinduced human pluripotent stem cellsinjured CNSinsular sclerosisintercellular communicationintervention developmentloss of functionmesogliamicroglial cellmicrogliocytemolecular profilemolecular signaturemouse modelmurine modelneural inflammationneurodegenerative illnessneuroinflammationneuroinflammatoryneurotraumanew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwayperivascular glial cellpreventpreventingprogramsre-myelinatere-myelinationreceptorrecruitremyelinateremyelinationrepairrepairedresectionresolutionsresponserestorationsNuc-Seqsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNAsnRNA sequencingsnRNA-seqsocial rolesubstantia albatherapy developmenttissue repairtranscriptomicstransgenictreatment developmenttumor microenvironmentuRNAvalidationswhite matterwhite matter damagewhite matter injury
Description preview
Project Summary
Clearance of cellular debris from the degenerating central nervous system (CNS) white matter is inefficient.
Debris accumulation, especially from myelin, precipitates maladaptive neuroinflammation which furthers disease
progression and prevents repair. Chronic white matter degeneration that produces cellular debris and protracted…
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