grant
Interplay Between Transcription and ATP-dependent Chromatin Remodeling for Genome Regulation
Organization UNIVERSITY OF NEBRASKA MEDICAL CENTERLocation OMAHA, UNITED STATESPosted 29 Jan 2026Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20251H-Purin-6-amine3-D3-Dimensional30 nm Chromatin Fiber30 nm Fiber3DATP phosphohydrolaseATPaseAcuteAddressAdenineAdenosine TriphosphataseAntibodiesAssayBasal Transcription FactorBasal transcription factor genesBase PairingBindingBioassayBiochemistryBiological AssayBiological ChemistryCUT&RUNCancersCell BodyCellsChromatinChromatin FiberChromatin Remodeling ComplexChromatin Remodeling FactorChromatin StructureChromosomal OrganizationChromosomal StructureChromosome OrganizationChromosome StructuresCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseCollaborationsCoupledDNADNA SequenceDNA mutationDeoxyribonucleic AcidDevelopmentDiseaseDisorderDrugsEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFamilyGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomeGenomicsHistonesHumanIn VitroIndividualKineticsLinkMalignant NeoplasmsMalignant TumorMapsMeasuresMedicationMethodologyMethylationModern ManModificationMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMolecular TargetMovementMutateMutationNebraskaNeurologicNeurologicalNucleosomesOncogenicOutcome StudyPermeabilityPharmaceutical PreparationsPositionPositioning AttributeProcessProtein FootprintingProteinsRNA ExpressionRegulationRegulatory ProteinResearchResolutionRoleShapesSurfaceTechniquesTechnologyTestingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesVitamin B4Workbody movementbrahmacell typechromatin modifierchromatin remodelingconformationconformationalconformational stateconformationallyconformationsdevelopmentaldevelopmental diseasedevelopmental disorderdrug/agentepigeneticallyepigenomicsgenetic regulatory proteingenome mutationgenome scalegenome-widegenomewideinsightlong read seqlong-read sequencinglong-read transcript sequencingmalignancyneoplasm/cancernovelprogramspromoterpromotorregulatory gene productresolutionssmall molecular inhibitorsmall moleculesmall molecule inhibitorsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthree dimensionaltranscription factor
Description preview
(RPL Brahma, Sandipan: "Interplay Between Transcription and ATP-dependent Chromatin Remodeling for Genome Regulation")
Epigenetic control of gene expression is intricately linked to the organization of chromosomal nucleosomes
and regulatory proteins within chromatin, which governs DNA accessibility and spatial arrangement within
folded…
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