grant
Interplay Between Langerhans Cells and Sensory Neurons: Impact on Wound Healing and Nociception Following Burn Injuries
Organization UNIVERSITY OF MIAMI SCHOOL OF MEDICINELocation CORAL GABLES, UNITED STATESPosted 15 Sept 2024Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AcuteAffectAfferent NeuronsAnimal ModelAnimal Models and Related StudiesBehaviorBlood monocyteBone MarrowBone Marrow Reticuloendothelial SystemBurn injuryBurnsCalciumCationsCell CommunicationCell FunctionCell InteractionCell PhysiologyCell ProcessCell-to-Cell InteractionCellular FunctionCellular PhysiologyCellular ProcessChimeraChimera organismChronologyComprehensionDREADDsDataEpidermisEsthesiaExhibitsFree Nerve EndingGeneticGoalsHealth CareHematopoieticImageIn VitroIndividualItchingKnowledgeLangerhans cellLightMarrow monocyteMeasuresMediatingMedicalMethodsMiceMice MammalsModelingMolecularMonitorMurineMusNerveNerve CellsNerve UnitNeural CellNeurocyteNeuronsNociceptionNociceptive ImpulseNociceptive StimulusPainPainfulPatientsPhotoradiationPlayPopulationPopulation HeterogeneityProcessPropertyPruritic DisorderPruritisPruritusPsychologic StressPsychological StressPublishingQOLQuality of lifeRoleSamplingSensationSensory NeuronsSkinSubcellular ProcessTestingTherapeuticTransgenic MiceUnited StatesWound Repairbehavior responsebehavioral responseburn woundburnedcandidate biomarkercandidate identificationcandidate markerchimerasdesigner receptors exclusively activated by designer drugsdiverse populationshealinghemopoieticheterogeneous populationimagingimprovedin vitro activityin vivoinnovateinnovationinnovativeinsightitch sensationmodel of animalmonocytemouse modelmurine modelneuronalnew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynociceptivenovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoptogeneticspopulation diversityrecruitreinnervatereinnervationresponsescRNA sequencingscRNA-seqselective expressionselectively expressedsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletissue woundtooltreat woundwoundwound assessmentwound carewound healingwound managementwound monitoringwound recoverywound resolutionwound therapeuticswound therapywound treatmentwoundingwounds
Description preview
PROJECT SUMMARY
Effective wound care is of paramount importance for individuals who have sustained burn injuries.
Wound healing is intricately associated with the sensations of itching and pain, which can significantly impact a
patient's quality of life. Following a burn injury, monocyte-derived Langerhans cells (LCs) are mobilized from
the bone…
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