grant
Internal Dynamics of the Postsynaptic Density
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 18 Nov 2024Deadline 31 Oct 2029
NIHUS FederalResearch GrantFY2025Active Follow-upAddressAdoptedArchitectureAtlasesBehaviorBehavioralBindingBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCharacteristicsCognition DisordersCollaborationsCommunicationComplexDNADataData SetDeoxyribonucleic AcidDevelopmentDiseaseDisorderDockingDysfunctionEmergent TechnologiesEmerging TechnologiesEncephalonEngineering / ArchitectureEnvironmentExcitatory SynapseFunctional disorderGatekeepingGenerationsGeneticGenetics-MutagenesisGlutamate ReceptorGlutamatesHLA-DR Associated Protein IIHumanIGAADImageImaging ProceduresImaging TechnicsImaging TechniquesIndividualInformation StorageInhibitor of GZMA-Activated DNaseIntracellular Communication and SignalingIntracellular StructureInvestigationIon ChannelIonic ChannelsKnock-inKnock-outKnockoutKnowledgeL-GlutamateLinkLiteratureMachine LearningMeasuresMediatingMembrane ChannelsModelingModern ManMolecularMolecular AnalysisMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMolecular StereochemistryMutagenesisMutagenesis Molecular BiologyN Methyl D aspartic AcidN methyl D aspartateN-Methyl-D-Aspartate ReceptorsN-Methyl-D-aspartateN-MethylaspartateN-Methylaspartate ReceptorsNMDANMDA Receptor-Ionophore ComplexNMDA ReceptorsNanostructuresNatureNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeural TransmissionNeurocyteNeuronal TransmissionNeuronsNeurosciencesOpticsPathologicPerformancePhosphatase 2A Inhibitor I2PP2APhysiologicPhysiologicalPhysiologyPhysiopathologyPlayPositionPositioning AttributeProbabilityProteinsReceptor ActivationReceptor ProteinReceptor SignalingResolutionRoleSET Translocation Inhibitor-2 of Protein Phosphatase-2ASet proteinShapesSignal TransductionSignal Transduction SystemsSignalingSiteStructureSubcellular ProcessSubcellular structureSynapsesSynapticSynaptic TransmissionSynaptic plasticityTemplate Activating Factor I BetaTestingTimeTransmissionVesicleWorkactive followupantagonismantagonistaxon signalingaxon-glial signalingaxonal signalingbiological signal transductionbrain shapecartilage link proteincognitive capacitycognitive diseasecognitive disordercognitive syndromecomputer based predictionconformationconformationalconformational stateconformationallyconformationsdensitydetectordevelopmentaldevelopmental diseasedevelopmental disorderflexibilityflexiblefollow upfollow-upfollowed upfollowupgatekeeperglia signalingglial signalingglutamatergicimaginginsightknockinlink proteinmachine based learningmolecular modelingnanonano meter scalenano meter sizednano-architecturenano-sized structuresnano-structuresnanoarchitecturenanocolumnnanoimagingnanometer scalenanometer sizednanoscalenerve signalingneural signalingneuronalneuronal signalingneurotransmissionnew approachesnovelnovel approachesnovel strategiesnovel strategyoperationoperationsopticalpathophysiologypharmacologicpostsynapticpredictive modelingpresynapticprotein complexreceptorresolutionsscaffoldscaffoldingsocial rolestatistical learningstructural biologysuccesssuperresolution imagingsynapsesynapse functionsynaptic functiontooltraffickingtransmission processvoltage
Description preview
NMDA-type glutamate receptors (NMDARs) shape brain development, synaptic transmission, and disease by acting both as central gatekeepers of synaptic plasticity and as hubs for synaptic protein organization. Strong genetic link between NMDAR subunits and numerous developmental and cognitive disorders places high importance on understanding both the…
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