grant
Intercellular Communication in Cancer Cachexia: Impact of Obesity and Exercise
Organization COLORADO STATE UNIVERSITYLocation FORT COLLINS, UNITED STATESPosted 1 Sept 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY2026AdipocytesAdipose CellAdipose tissueAdvanced CancerAdvanced Malignant NeoplasmAffectAnimal ModelAnimal Models and Related StudiesAutoregulationAwardBioinformaticsBiologyBlood PlasmaBody SystemBody TissuesCachecticCachexiaCancer BiologyCancer CachexiaCancer InductionCancer PatientCancer SurvivorCancersCell Communication and SignalingCell Culture TechniquesCell FunctionCell PhysiologyCell ProcessCell SignalingCell to Cell Communication and SignalingCell-Cell SignalingCellular FunctionCellular PhysiologyCellular ProcessCellular biologyClinical ResearchClinical StudyColoradoCommunicationDataDevelopmentDevelopment PlansDiabetes MellitusDiagnosisDysfunctionEndocrinologyExerciseFat CellsFatsFatty TissueFatty acid glycerol estersFellowshipFunctional disorderFundingFunding OpportunitiesFutureGoalsHealthHomeostasisHumanImpairmentInflammationInflammation MediatorsInflammatoryInstitutionIntermediary MetabolismInterventionIntracellular Communication and SignalingInvestigatorsKnowledgeLeannessLinkLipidsLipocytesMalignant NeoplasmsMalignant TumorMature LipocyteMature fat cellMediatingMediatorMentorsMentorshipMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolic dysfunctionMetabolismMetabolism and EndocrinologyMiceMice MammalsMitochondriaModern ManMorphologyMurineMusMuscleMuscle AtrophyMuscle FibersMuscle MitochondriaMuscle TissueMuscle functionMuscular AtrophyMyotubesNIDDKNational Institute of Diabetes and Digestive and Kidney DiseasesNon-Polyadenylated RNANutritionObese MiceObesityOncologyOncology CancerOrgan SystemOutcomeOverweightPathogenesisPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhysical FunctionPhysiological AdaptationPhysiological HomeostasisPhysiologyPhysiopathologyPlasmaPlasma SerumPrevalenceProteomicsQOL improvementQuality ControlRNARNA Gene ProductsReportingResearchResearch PersonnelResearchersRespirationReticuloendothelial System, Serum, PlasmaRhabdomyocyteRibonucleic AcidRoleSarcosomesSeveritiesSignal TransductionSignal Transduction SystemsSignalingSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSubcellular ProcessTechnical ExpertiseTestingTherapeuticThesaurismosisThinnessTimeTissuesTrainingTranslational ResearchTranslational ScienceTreatment outcomeTumor-DerivedUniversitiesVoluntary MuscleWasting DiseaseWasting SyndromeWeightWorkadiposeadiposityanti-cancer researchbiological signal transductioncancer associated cachexiacancer diagnosiscancer induced cachexiacancer researchcancer-associated muscle wastingcancer-induced muscle atrophycancer-induced muscle losscancer-induced muscle wastingcancer-related cachexiacarcinogenesiscareercareer developmentcell biologycell culturecell culturescorpulencedevelopmentaldiabetesexercise interventionexperienceextracellular vesiclesfunctional outcomesimprovedimproved outcomeimprovements in QOLimprovements in quality of lifeinflammation markerinflammatory markerinflammatory mediatorinsightintercellular communicationlipid mediatormalignancymetabolic phenotypemetabolism disordermetabotypemitochondrialmitochondrial dysfunctionmodel of animalmuscle breakdownmuscle bulkmuscle degradationmuscle deteriorationmuscle formmuscle lossmuscle massmuscle wastingmuscularnano particlenano-sized particlenanoparticlenanosized particleneoplasm/cancernovelob/ob mousepathophysiologypatient oriented outcomesphysical activity interventionpotential biological markerpotential biomarkerquality of life improvementrespiratory mechanismresponseskeletal muscle atrophyskeletal muscle breakdownskeletal muscle lossskeletal muscle protein lossskeletal muscle wastingskillssocial rolesurvivorshipsystemic inflammationsystemic inflammatory responsetechnical skillstherapeutic targettherapeutically effectivetraffickingtranslation researchtranslational investigationtumortumor-induced cachexiatumor-induced muscle wastingvesicle releasevesicular releasewasting conditionwasting disorderweightswhite adipose tissueyellow adipose tissue
Description preview
Research: At the time of cancer diagnosis, 40%–60% of patients are overweight or obese. Despite this, there is a lack in understanding how pre-existing obesity influences the development and severity of cancer cachexia— a multifactorial wasting syndrome characterized by the unintentional loss of lean mass, which contributes to poor physical…
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